Voveran SR (diclofenac sodium sustained release) is a prescription nonsteroidal anti-inflammatory drug (NSAID) designed for the management of chronic pain and inflammatory conditions. Its sustained-release formulation ensures prolonged therapeutic effect, reducing dosing frequency and supporting consistent symptom control. This medication is indicated for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, providing targeted relief where long-term anti-inflammatory and analgesic action is required. Always use under medical supervision to maximize benefits and minimize risks.

Features

• Active ingredient: Diclofenac sodium 100 mg
• Form: Sustained-release tablet
• Mechanism: Cyclooxygenase (COX) inhibition, reducing prostaglandin synthesis
• Duration: 24-hour controlled release for steady plasma concentration
• Prescription-only medication

Benefits

• Provides continuous relief from chronic inflammatory pain, improving daily function and mobility.
• Reduces joint stiffness and swelling associated with arthritis, enhancing quality of life.
• Minimizes dosing frequency to once daily, supporting adherence and convenience.
• Targets pain at the source through potent anti-inflammatory and analgesic properties.
• Helps restore range of motion and physical activity in appropriately selected patients.

Common use

Voveran SR is commonly prescribed for the management of chronic musculoskeletal and joint disorders. Its primary indications include osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It may also be used off-label for other persistent pain conditions where sustained anti-inflammatory effect is beneficial, such as chronic lower back pain or soft tissue disorders. It is not intended for acute pain episodes.

Dosage and direction

The typical adult dosage is one 100 mg sustained-release tablet taken once daily, swallowed whole with fluid, preferably with food or milk to minimize gastrointestinal upset. Do not crush, chew, or break the tablet, as this alters the release profile. Dosage should be individualized based on condition severity, patient response, and risk factors. The lowest effective dose for the shortest duration should be used. Elderly patients or those with hepatic or renal impairment may require dose adjustment.

Precautions

Use with caution in patients with a history of gastrointestinal ulceration or bleeding, cardiovascular disease, hypertension, renal impairment, hepatic dysfunction, asthma, or dehydration. Avoid prolonged use without periodic monitoring of renal function, liver enzymes, hemoglobin, and blood pressure. Patients should be advised to report any signs of gastrointestinal bleeding, edema, skin reactions, or unexplained weight gain. Use during pregnancy, especially in the third trimester, is contraindicated.

Contraindications

Hypersensitivity to diclofenac, aspirin, or other NSAIDs; history of asthma, urticaria, or allergic-type reactions after taking NSAIDs; peri-operative pain in coronary artery bypass graft (CABG) surgery; active peptic ulcer disease or gastrointestinal bleeding; severe heart failure; advanced renal impairment; third trimester of pregnancy.

Possible side effects

Common side effects include dyspepsia, nausea, abdominal pain, diarrhea, headache, and dizziness. Less frequently, edema, hypertension, elevated liver enzymes, skin rash, or pruritus may occur. Serious adverse effects can include gastrointestinal ulceration or bleeding, cardiovascular thrombotic events, renal toxicity, severe skin reactions, and hepatotoxicity. Discontinue and seek medical attention if severe side effects develop.

Drug interaction

Vorenan SR may interact with anticoagulants (e.g., warfarin), antiplatelet agents, other NSAIDs, corticosteroids, ACE inhibitors, angiotensin II receptor blockers, diuretics, lithium, methotrexate, cyclosporine, and SSRIs, increasing the risk of bleeding, nephrotoxicity, or hypertension. Concomitant use with other NSAIDs or corticosteroids should be avoided. Consult a healthcare provider for a comprehensive medication review.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule. Consistent daily administration is important to maintain therapeutic effect.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, drowsiness, dizziness, tinnitus, or seizures. Rarely, acute renal failure or respiratory depression may occur. There is no specific antidote; management is supportive and symptomatic. Gastric lavage or activated charcoal may be considered if presented early. Hemodialysis is not effective due to high protein binding.

Storage

Store at room temperature (15–30°C), in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis, treatment decisions, and personalized recommendations. Do not initiate, adjust, or discontinue medication without medical supervision.

Reviews

Clinical studies and patient reports indicate that Voveran SR is effective in managing chronic inflammatory pain, with many users noting improved mobility and reduced discomfort. Some report gastrointestinal side effects, emphasizing the need for concomitant gastroprotective agents in high-risk individuals. Overall, it is regarded as a valuable option for long-term NSAID therapy when used appropriately under guidance.