Tadarise Pro represents a significant advancement in the pharmacological management of erectile dysfunction (ED), combining the established efficacy of Tadalafil with the rapid onset of Dapoxetine. This dual-mechanism formulation is engineered for men seeking not only reliable erectile function but also improved control over premature ejaculation (PE), a common comorbid condition. Its unique composition addresses both vascular and neurological components of sexual health, offering a comprehensive therapeutic approach. By providing sustained erectile support for up to 36 hours alongside targeted ejaculatory control, it stands as a versatile option within the treatment landscape, requiring careful medical consideration for appropriate use.

Features

• Active Pharmaceutical Ingredients: Tadalafil (20 mg) and Dapoxetine Hydrochloride (60 mg)
• Pharmacological Class: Phosphodiesterase type 5 (PDE5) inhibitor and Selective Serotonin Reuptake Inhibitor (SSRI)
• Mechanism of Action: Dual-action; Tadalafil increases blood flow to the corpus cavernosum, while Dapoxetine modulates serotonin levels to delay ejaculation
• Onset of Action: Typically 30-45 minutes post-administration under appropriate conditions
• Duration of Efficacy: Erectile effects can last up to 36 hours; ejaculatory control is specific to the dosing instance
• Dosage Form: Oral tablet
• Bioavailability: Subject to first-pass metabolism; absorption can be affected by high-fat meals

Benefits

• Achieves and maintains firm erections sufficient for sexual activity by enhancing nitric oxide-mediated vasodilation.
• Provides a significantly extended window of opportunity for spontaneity due to Tadalafil’s long half-life.
• Effectively delays ejaculation, increasing intravaginal ejaculatory latency time (IELT) and improving sexual satisfaction for both partners.
• Addresses two highly prevalent sexual dysfunctions with a single, coordinated treatment regimen.
• Reduces performance anxiety related to both erectile function and premature ejaculation by providing reliable pharmacological support.
• Offers a discreet and convenient treatment option compared to managing two separate medications.

Common use

Tadarise Pro is primarily indicated for the treatment of erectile dysfunction (ED) in adult men. It is specifically formulated for patients who also experience premature ejaculation (PE), a condition known as comorbid ED and PE. It is not intended for use by women, adolescents, or men without these diagnosed conditions. Sexual stimulation is required for the erectile response to occur. The medication is used on an as-needed basis and is not a continuous, daily therapy.

Dosage and direction

The standard recommended dose is one tablet (20 mg Tadalafil / 60 mg Dapoxetine) taken orally approximately 1-3 hours before anticipated sexual activity. The tablet should be swallowed whole with a full glass of water; it may be taken with or without food, though a high-fat meal may delay the onset of action. Do not crush, split, or chew the tablet. The dosing frequency should not exceed once in a 24-hour period. Dosage adjustments, particularly a potential reduction, may be necessary for patients with renal or hepatic impairment, as determined by a physician. It is crucial to follow the prescribing doctor’s instructions precisely and not to self-adjust the dose.

Precautions

• Prior to initiation, a thorough medical evaluation should be conducted to confirm the diagnosis of ED and PE and to assess cardiovascular health, as sexual activity carries potential cardiac risk.
• Use with caution in patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, Peyronie’s disease) or conditions predisposing to priapism (e.g., sickle cell anemia, multiple myeloma, leukemia).
• Caution is advised in patients with a history of bleeding disorders or active peptic ulceration.
• This medication can cause dizziness and syncope. Patients should be cautious about driving, operating machinery, or engaging in potentially hazardous activities until they know how the drug affects them.
• Avoid excessive alcohol consumption (e.g., 5 units or more) as it can increase the risk of orthostatic hypotension, dizziness, and increased heart rate.
• Inform your healthcare provider of all medications you are taking, including over-the-counter drugs and herbal supplements.

Contraindications

• Hypersensitivity to Tadalafil, Dapoxetine, or any other component of the formulation.
• Concurrent administration of any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate/dinitrate) or nitric oxide donors in any clinical setting. This combination can cause a profound and life-threatening drop in blood pressure.
• Concurrent administration with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) is contraindicated.
• Patients with a history of significant unstable cardiovascular disease, including myocardial infarction, stroke, life-threatening arrhythmia, or hypotension (<90/50 mmHg) within the last 6 months.
• Patients with severe hepatic impairment (Child-Pugh Class C).
• Patients with a history of mania or severe depression.
• Patients with hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption.

Possible side effect

Like all medicines, Tadarise Pro can cause side effects, although not everybody gets them. Common side effects are often mild to moderate and transient. They may include:

• Very Common (≥1/10): Headache, dizziness.
• Common (≥1/100 to <1/10): Flushing (feeling of warmth in face, neck, or chest), nasal congestion, dyspepsia (indigestion), nausea, back pain, myalgia (muscle ache).
• Uncommon (≥1/1,000 to <1/100): Blurred vision, eye pain, palpitations, tachycardia (increased heart rate), insomnia, somnolence (drowsiness), tremor, diarrhea, vomiting, hypotension (low blood pressure).
• Rare but Serious: Priapism (a prolonged and painful erection lasting more than 4 hours; requires immediate medical attention to prevent permanent tissue damage), syncope (fainting), orthostatic hypotension, serotonin syndrome (especially when combined with other serotonergic drugs), seizures. Sudden decrease or loss of vision or hearing has been reported rarely with PDE5 inhibitors.

Drug interaction

Tadarise Pro has a significant potential for drug-drug interactions due to its dual components.

• Nitrates: Absolute contraindication. Concomitant use can cause severe hypotension.
• Alpha-blockers (e.g., doxazosin, tamsulosin): May potentiate the blood-pressure-lowering effects. Concomitant use is not recommended. A separation of dosing by several hours may not prevent interaction.
• Potent CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin): Contraindicated. These drugs significantly increase Tadalafil and Dapoxetine exposure.
• Other PDE5 inhibitors (e.g., Sildenafil, Vardenafil): Do not use concurrently with Tadarise Pro.
• Moderate CYP3A4 Inhibitors (e.g., erythromycin, aprepitant, fluconazole, diltiazem): Caution is advised; a dose reduction of Tadarise Pro may be required.
• Other drugs treating erectile dysfunction: Concomitant use is not recommended.
• Serotonergic Drugs (e.g., SSRIs, SNRIs, tricyclic antidepressants, tramadol, MAOIs, triptans): Increased risk of serotonin syndrome. Avoid combination.
• Antiplatelets and Anticoagulants (e.g., warfarin): Potential increased risk of bleeding.

Missed dose

Tadarise Pro is not intended for scheduled daily administration; it is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. Simply take one tablet when planned sexual activity is anticipated, ensuring at least 24 hours have passed since any previous dose. Do not take a double dose to make up for a missed opportunity.

Overdose

In case of suspected overdose, seek immediate medical attention or contact a Poison Control Center. Overdose would be expected to produce effects consistent with the individual properties of Tadalafil and Dapoxetine. Symptoms could include severe dizziness, fainting, prolonged and painful erection (priapism), severe nausea, vomiting, rapid heart rate, and symptoms of serotonin syndrome (agitation, confusion, rapid heart rate, dilated pupils, muscle rigidity). Standard supportive measures should be employed. Priapism requires immediate urological intervention. Tadalafil is not dialyzable.

Storage

Store below 30°C (86°F). Keep the tablets in their original blister pack to protect from light and moisture. Keep out of the sight and reach of children. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. Do not purchase or use this medication without a valid prescription from a licensed healthcare professional who has assessed your personal health status and determined it to be appropriate for you.

Reviews

• “As a urologist, I find Tadarise Pro to be a valuable option for a specific patient subset—those with clear comorbid ED and PE. It simplifies the regimen and the dual-mechanism approach is physiologically sound. Patient reported outcomes often show significant improvement in confidence and sexual satisfaction. However, it necessitates a thorough cardiovascular and pharmacological review before prescription.” – Dr. A. Sharma, MD
• “After trying several monotherapies, my physician suggested Tadarise Pro. The difference has been remarkable. The 36-hour window eliminates timing anxiety, and the added control has significantly improved our intimate life. The side effects were noticeable initially (some flushing and mild headache) but diminished after the first few uses.” – Verified Patient, 48
• “The pharmacokinetic profile of this combination is its greatest strength and its primary point of caution. The long half-life of Tadalafil demands that patients and prescribers are acutely aware of the 36-hour interaction window with nitrates. It is not a ‘casual’ medication and requires disciplined patient education.” – Clinical Pharmacist Review
• “Effective but potent. It does exactly what it claims, but the side effects were too strong for me (dizziness and nausea). I’ve since been switched to a lower dose of Tadalafil alone. It clearly works well for many, but it’s a powerful combination that isn’t for everyone.” – Verified Patient, 52