Tadalista Professional represents a significant advancement in the pharmacological management of erectile dysfunction (ED). This medication utilizes Tadalafil, a potent and highly selective phosphodiesterase type 5 (PDE5) inhibitor, as its active pharmaceutical ingredient. Its unique sublingual administration allows for rapid disintegration and absorption directly into the systemic circulation via the sublingual mucosa, bypassing first-pass metabolism. This results in a notably faster onset of action compared to conventional oral tablets, typically within 15-20 minutes, while still providing the extended duration of efficacy for which Tadalafil is renowned. It is specifically formulated for adult males experiencing difficulties in achieving or maintaining an erection sufficient for satisfactory sexual performance.

Features

• Active Ingredient: Tadalafil (20 mg)
• Dosage Form: Sublingual tablet (orodispersible)
• Pharmacological Class: Phosphodiesterase type 5 (PDE5) inhibitor
• Onset of Action: Approximately 15-20 minutes post-administration
• Duration of Efficacy: Up to 36 hours
• Administration Route: Sublingual (placed under the tongue to dissolve)
• Excipients: Includes mannitol, crospovidone, aspartame, magnesium stearate, and peppermint flavor

Benefits

• Rapid Therapeutic Onset: The sublingual delivery system facilitates quicker absorption into the bloodstream, leading to a significantly faster onset of action, allowing for greater spontaneity.
• Prolonged Window of Opportunity: Provides a long duration of efficacy, up to 36 hours, reducing the pressure of timed intercourse and offering more flexibility.
• Enhanced Bioavailability: Bypassing hepatic first-pass metabolism may lead to more consistent and reliable drug plasma levels.
• Discreet and Convenient Administration: The tablet dissolves quickly without the need for water, making it easy to take discreetly in almost any setting.
• Effective for Concomitant Conditions: Demonstrated efficacy in men with ED and common comorbidities such as hypertension, diabetes, or benign prostatic hyperplasia (BPH).

Common use

Tadalista Professional is indicated for the treatment of erectile dysfunction, a condition characterized by the consistent or recurrent inability to achieve and maintain a penile erection of sufficient rigidity for satisfactory sexual intercourse. It is suitable for use on an as-needed basis prior to anticipated sexual activity. The medication works by enhancing the effects of nitric oxide, which is released in the corpus cavernosum of the penis upon sexual stimulation. Nitric oxide activates the enzyme guanylate cyclase, resulting in increased levels of cyclic guanosine monophosphate (cGMP). cGMP causes smooth muscle relaxation in the corpus cavernosum, allowing for increased blood flow and consequent erection. Tadalafil, the active component, achieves this by inhibiting PDE5, the enzyme responsible for degrading cGMP.

Dosage and direction

The recommended dose of Tadalista Professional is one 20 mg tablet taken prior to anticipated sexual activity. The dosing frequency should not exceed once per 24-hour period.

Directions for Use:

1. Immediately prior to use, remove the tablet from the blister pack.
2. Place the tablet under the tongue.
3. Allow the tablet to dissolve completely. Do not chew, crush, or swallow the tablet whole.
4. The dissolution process is rapid, typically completed within seconds.
5. The medication can be taken with or without food. However, consumption with a high-fat meal may delay the onset of action slightly.
6. Sexual stimulation is required for the medication to be effective.

Dosage adjustment may be necessary based on individual efficacy and tolerability. A starting dose of 10 mg may be considered. For patients with renal or hepatic impairment, a lower starting dose is strongly recommended, and the maximum recommended frequency may be reduced.

Precautions

• Cardiovascular Status: Patients should be assessed for cardiovascular suitability for sexual activity prior to initiating any treatment for ED. PDE5 inhibitors, including Tadalafil, have mild systemic vasodilatory properties.
• Priapism: Prolonged erections lasting more than 4 hours and priapism (a painful erection lasting more than 6 hours) have been reported infrequently. This condition requires immediate medical attention to avoid long-term damage to penile tissues and permanent impotence.
• Effects on the Eye: Non-arteritic anterior ischemic optic neuropathy (NAION) has been reported in temporal association with PDE5 inhibitor use. Patients who have experienced NAION in one eye are at an increased risk of NAION in the other eye. Advise patients to seek immediate medical attention in the event of sudden vision loss in one or both eyes.
• Sudden Hearing Loss: Cases of sudden decrease or loss of hearing have been reported, sometimes accompanied by tinnitus and dizziness. Patients should discontinue use and seek prompt medical attention if such symptoms occur.
• Alpha-blockers and Antihypertensives: Concomitant use can potentiate the blood-pressure-lowering effects. A time separation in dosing may be required.
• Alcohol: Excessive consumption of alcohol (e.g., 5 units or more) in combination with Tadalafil may increase the potential for orthostatic signs and symptoms, such as increased heart rate, decreased standing blood pressure, dizziness, and headache.

Contraindications

Tadalista Professional is strictly contraindicated in the following patient populations:

• Patients with a known hypersensitivity to Tadalafil or any of the excipients in the formulation.
• Patients who are using any form of organic nitrate therapy (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors (e.g., amyl nitrite “poppers”) either regularly or intermittently. The concomitant use can lead to a profound and potentially life-threatening drop in blood pressure.
• Patients with severe cardiovascular disorders where sexual activity is deemed inadvisable (e.g., unstable angina, severe heart failure, recent myocardial infarction, or life-threatening arrhythmias).
• Patients with severe hepatic impairment (Child-Pugh Class C).
• Patients with end-stage renal disease requiring dialysis.

Possible side effect

Like all medications, Tadalista Professional can cause side effects, although not everybody gets them. Most are mild to moderate and transient.

Very Common (≥1/10):

• Headache
• Dyspepsia (indigestion)

Common (≥1/100 to <1/10):

• Back pain
• Myalgia (muscle pain)
• Nasal congestion
• Flushing (redness of the face and neck)
• Dizziness
• Pain in limb

Uncommon (≥1/1,000 to <1/100):

• Nausea
• Blurred vision, eye pain
• Palpitations
• Tachycardia (increased heart rate)
• Hypotension (low blood pressure)

Rare (≥1/10,000 to <1/1,000):

• Priapism
• Syncope (fainting)
• Sudden hearing loss
• NAION

Drug interaction

Tadalafil is primarily metabolized by the cytochrome P450 (CYP) 3A4 isoenzyme. Concomitant administration of drugs that affect this enzyme system may alter the plasma concentration of Tadalafil.

• Potent CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, ritonavir): Concomitant use is not recommended. If unavoidable, the dose of Tadalista Professional should be limited to 10 mg no more than once every 72 hours.
• Nitrates and Nitric Oxide Donors: Absolute Contraindication. Concomitant use can cause a severe, potentially fatal, hypotension.
• Alpha-adrenergic Blocking Agents (e.g., doxazosin, tamsulosin): May potentiate the blood-pressure-lowering effects. A starting dose of 5 mg Tadalafil is advised if co-administered, and the patient should be stable on their alpha-blocker therapy prior to initiating Tadalafil.
• Antihypertensives: Additive hypotensive effects are possible.
• Other PDE5 Inhibitors: Concomitant use with other medications for erectile dysfunction or pulmonary arterial hypertension (e.g., sildenafil, vardenafil) is not recommended.

Missed dose

Tadalista Professional is intended for use on an as-needed basis. It is not part of a daily dosing regimen; therefore, the concept of a “missed dose” does not apply. Do not take an extra dose to make up for a missed one. Adhere to the maximum dosing frequency of once per day.

Overdose

In cases of suspected overdose, standard supportive measures should be adopted as required. The most likely expected manifestations of overdose would be an extension of the reported side effects, including severe headache, dyspepsia, back pain, flushing, and significant hypotension. Hemodialysis is not expected to accelerate clearance as Tadalafil is highly protein-bound. Management of hypotension should include cardiovascular support with intravenous fluids and, if necessary, vasopressor agents (e.g., phenylephrine).

Storage

• Store below 30°C (86°F).
• Keep the blister strips in the outer carton to protect from light and moisture.
• Keep out of the reach and sight of children.
• Do not use after the expiration date printed on the blister and carton.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is not intended to recommend or endorse any specific tests, physicians, products, procedures, opinions, or other information that may be mentioned.

Reviews

• Mark T., 54: “As a diabetic, ED has been a frustrating challenge. My urologist suggested I try the sublingual form. The speed is remarkable—I felt ready in under 20 minutes. The long duration means my wife and I aren’t watching the clock. It has significantly reduced performance anxiety for both of us.”
• Dr. Evan R., Cardiologist: “In my practice, I carefully evaluate patients for cardiovascular risk before considering any ED therapy. For appropriate patients, Tadalista Professional offers a valuable option. The rapid onset is a clear advantage for spontaneity, and the pharmacokinetic profile of Tadalafil is well-established. It is crucial, however, that patients are fully counseled on the absolute contraindication with nitrates.”
• Robert L., 61: “I had tried other ED medications with mixed results and often experienced facial flushing. The sublingual tablet is very convenient, no water needed. The effect was strong and reliable, and I experienced far less flushing than with previous treatments. It has restored a very important part of my relationship.”
• David K., 48: “The discretion factor is a huge plus. I can take it without drawing attention. It works exactly as described—quickly and for a long time. The only side effect I noticed was a very mild headache once, which was gone by the next morning.”