Sildigra Softgel represents a significant advancement in the oral pharmacotherapy of erectile dysfunction (ED), offering a patient-centric formulation designed for enhanced efficacy and tolerability. This medication utilizes Sildenafil Citrate, a potent phosphodiesterase type 5 (PDE5) inhibitor, in a unique softgel delivery system that promotes rapid dissolution and predictable absorption. Clinically developed to address the physiological mechanisms underlying ED, it facilitates increased blood flow to the corpus cavernosum, enabling a satisfactory erectile response upon sexual stimulation. Its formulation is a testament to modern pharmaceutical design, prioritizing both therapeutic performance and user experience.

Features

• Active Pharmaceutical Ingredient: Sildenafil Citrate 100mg.
• Pharmaceutical Form: Oral softgel capsule.
• Mechanism of Action: Selective inhibition of phosphodiesterase type 5 (PDE5).
• Pharmacokinetic Profile: Rapid disintegration, with a mean time to maximum plasma concentration (Tmax) of approximately 30-60 minutes.
• Excipients: Includes solubilizers and absorption enhancers specifically selected for the softgel matrix.
• Packaging: Blister packs (ALU/ALU) for optimal stability and moisture protection.

Benefits

• Promotes a reliable and firm erection sufficient for sexual intercourse when combined with sexual stimulation.
• The softgel formulation may allow for a faster onset of action compared to traditional tablet forms.
• Designed for easier swallowing and potentially improved gastrointestinal tolerability.
• Supports restored sexual confidence and can improve overall sexual satisfaction for the patient and partner.
• The predictable pharmacokinetic profile allows for effective planning of sexual activity.

Common use

Sildigra Softgel is indicated for the treatment of erectile dysfunction (ED) in adult males. It is used on an as-needed basis to achieve and maintain an erection. It is important for patients to understand that sexual stimulation is required for the medication to be effective. It is not an aphrodisiac and does not increase libido.

Dosage and direction

The recommended starting dose for most patients is one 100mg softgel taken orally approximately 30-60 minutes before anticipated sexual activity. The dosage may be adjusted based on efficacy and tolerability down to 50mg or up to a maximum of 100mg, not to exceed one dose per 24-hour period. The softgel should be swallowed whole with a glass of water. It may be taken with or without food; however, a high-fat meal may delay the onset of action.

Precautions

• Prior to prescribing, a thorough medical history and physical examination should be conducted to diagnose ED, determine potential underlying causes, and identify appropriate treatment.
• Use with caution in patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie’s disease).
• Caution is advised in patients with conditions that may predispose them to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia).
• Cardiovascular status should be assessed, as sexual activity carries a potential cardiac risk. Sildigra Softgel is not recommended for use in men for whom sexual activity is inadvisable due to their cardiovascular status.
• Use with caution in patients with bleeding disorders or active peptic ulceration.

Contraindications

• Hypersensitivity to Sildenafil Citrate or any other component of the formulation.
• Concurrent administration of any form of organic nitrates or nitric oxide donors (e.g., amyl nitrite “poppers”) in any form, either regularly or intermittently.
• Concurrent administration with guanylate cyclase stimulators, such as riociguat.
• Patients with severe hepatic impairment (Child-Pugh class C).
• Patients with severe hypotension (BP <90/50 mmHg).
• Patients with recent history of stroke or myocardial infarction.
• Patients with known hereditary degenerative retinal disorders, including retinitis pigmentosa.

Possible side effect

Sildenafil Citrate is a potent vasodilator, and side effects are generally mild to moderate and transient. They are often related to the drug’s pharmacodynamic profile.

• Very Common (≥1/10): Headache, flushing.
• Common (≥1/100 to <1/10): Dyspepsia, nasal congestion, dizziness, visual disturbances (including blurred vision, cyanopsia, and increased light perception).
• Uncommon (≥1/1,000 to <1/100): Hypotension, tachycardia, palpitations, syncope, hematuria, eye pain, photophobia, erythema.
• Rare (≥1/10,000 to <1/1,000): Priapism (prolonged and sometimes painful erection lasting more than 4 hours), sudden hearing loss, non-arteritic anterior ischemic optic neuropathy (NAION).
• Frequency not known: Hypersensitivity reactions (including skin rashes).

Drug interaction

Sildenafil Citrate is primarily metabolized by CYP isoforms 3A4 (major route) and 2C9 (minor route). Co-administration with inhibitors or inducers of these enzymes will affect plasma concentrations.

• Absolute Contraindication: Nitrates (e.g., nitroglycerin, isosorbide mononitrate/dinitrate) and recreational drugs called “poppers” (amyl nitrite) cause profound hypotension.
• Potent CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin): Concomitant use will significantly increase sildenafil plasma levels. A maximum dose of 25mg within a 48-hour period is recommended.
• Alpha-blockers (e.g., doxazosin, tamsulosin): Concomitant use can lead to symptomatic hypotension. Dose separation or alternative therapy should be considered.
• Other Antihypertensives: May potentiate the hypotensive effect.
• CYP3A4 Inducers (e.g., rifampicin, carbamazepine, St. John’s Wort): May reduce sildenafil plasma levels, decreasing efficacy.

Missed dose

Sildigra Softgel is not intended for scheduled daily dosing. It is taken on an as-needed basis. A “missed dose” is not applicable. Do not take more than one dose in a 24-hour period.

Overdose

In cases of overdose, the primary expected effects would be an extension of the drug’s known vasodilatory properties. Symptoms could include severe headache, profound hypotension, syncope, prolonged erection, and visual disturbances. Standard supportive measures should be employed, including keeping the patient in the supine position to maintain blood pressure. Hemodialysis is not expected to accelerate clearance, as sildenafil is highly protein-bound and extensively metabolized.

Storage

Store below 30°C (86°F). Keep the blister packs in the outer carton to protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

• “As a urologist, the softgel formulation has been a welcome option for patients who have difficulty swallowing tablets or report slower onset with other forms. The efficacy profile remains consistent with Sildenafil, which is the gold standard.” – Dr. Evan R., MD
• “Noticed the effects came on slightly quicker than the pill version I used to take. It was effective and the experience was hassle-free.” – Mark T.
• “The predictable results have helped restore a sense of normalcy to my relationship. I appreciate the discreet packaging as well.” – James L.
• “While effective, I did experience the expected flushing and a minor headache. It was manageable and subsided after a few hours.” – Robert K.