Zovirax Cream (acyclovir 5%) is a topical antiviral medication specifically formulated for the management of initial and recurrent episodes of herpes simplex virus infections affecting the skin. It is indicated for the treatment of herpes labialis (cold sores) and limited non-life-threatening cutaneous herpes simplex infections in immunocompetent adult and pediatric patients. This cream formulation delivers acyclovir, a nucleoside analogue DNA polymerase inhibitor, directly to the site of viral replication, providing targeted antiviral activity while minimizing systemic exposure. Clinical studies demonstrate that early application can reduce healing time and viral shedding when used as directed by healthcare professionals.

Features

• Contains 5% acyclovir as the active pharmaceutical ingredient
• White, aqueous-based cream formulation
• Designed for topical application to affected skin areas
• Available in 2g and 5g tubes with precise dosage delivery
• Stable at room temperature with two-year shelf life
• Minimal systemic absorption with primarily local action
• Compatible with intact skin and mucous membranes

Benefits

• Reduces healing time of herpes simplex lesions when applied early
• Decreases duration of pain and discomfort associated with outbreaks
• Limits viral shedding and potential transmission to others
• Provides localized treatment with minimal systemic side effects
• Easy to apply with minimal residue or staining
• Suitable for both initial episodes and recurrent infections

Common use

Zovirax Cream is primarily indicated for the treatment of herpes labialis (cold sores) on the face and lips in immunocompetent adults and children 12 years of age and older. It is also used for the management of limited non-life-threatening cutaneous herpes simplex infections, including genital herpes outbreaks when applied to external lesions. The cream is most effective when applied at the earliest signs of infection, typically during the prodromal phase characterized by tingling, itching, or burning sensations before visible lesions appear. Clinical evidence supports its use for recurrent episodes, though effectiveness may diminish with delayed application.

Dosage and direction

Apply sufficient quantity to adequately cover all lesions every 3 hours, 6 times per day for 7 days. Wash hands before and after application. Use a finger cot or glove if applying to genital areas to prevent autoinoculation or transmission to other sites. Treatment should begin as early as possible following onset of signs and symptoms. The total treatment area should not exceed 25 cm² (approximately 5x5 cm) for adults or 12.5 cm² for children. Do not apply to mucous membranes except for the lips and external genitalia as directed. Avoid ocular application.

Precautions

For external use only. Avoid application in or near the eyes as it may cause irritation. Do not apply inside the mouth. Use with caution in patients with compromised skin barrier function or extensive lesions, as increased systemic absorption may occur. Immunocompromised patients may require concurrent systemic therapy and should be monitored closely. Discontinue use if sensitivity reactions occur. Not for prevention of recurrent infections. Sexual contact should be avoided when visible lesions are present even during treatment. Do not use on children under 12 years of age unless directed by a physician.

Contraindications

Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation. Contraindicated in patients with known propylene glycol hypersensitivity. Not recommended for use on mucous membranes except as specifically indicated for labial and genital applications. Should not be used for the treatment of varicella-zoster virus (chickenpox or shingles) or disseminated herpes simplex infections. Not indicated for ophthalmological use. Contraindicated in patients with severe renal impairment when considering potential systemic absorption through compromised skin.

Possible side effects

Common local reactions include mild pain, burning, or stinging at application site (approximately 30% of patients). Dryness or flaking of skin may occur. Less frequently reported effects include itching, erythema, and mild skin irritation. Rare cases of contact dermatitis and hypersensitivity reactions have been reported. Systemic effects are uncommon due to minimal absorption but may include headache, nausea, or dizziness in susceptible individuals. Angioedema and anaphylaxis are extremely rare but possible in hypersensitive patients.

Drug interaction

No significant drug interactions have been reported with topical aclovir application due to minimal systemic absorption. However, theoretical interactions with other nephrotoxic drugs should be considered in patients with extensive application to compromised skin barriers. Concurrent use with other topical products may alter absorption characteristics or cause physical incompatibility. Avoid concomitant use with other topical medications unless directed by a healthcare provider. No known interactions with oral contraceptives or commonly prescribed medications.

Missed dose

Apply the missed dose as soon as remembered, then resume regular dosing schedule. Do not double the dose to make up for the missed application. The effectiveness of treatment depends on consistent application during the waking hours. If multiple doses are missed, consult your healthcare provider regarding continued therapy. The antiviral effect is time-dependent, so maintaining the every-3-hour schedule during waking hours provides optimal results.

Overdose

Topical overdose is unlikely due to limited systemic absorption. However, excessive application to large body surface areas or compromised skin may lead to systemic effects including headache, nausea, diarrhea, and renal impairment. Accidental ingestion may cause gastrointestinal distress, headache, and neurological symptoms. In case of accidental ingestion, seek medical attention immediately. Treatment is supportive with attention to renal function. Hemodialysis may be considered in significant ingestions.

Storage

Store at room temperature between 15-25°C (59-77°F). Do not freeze. Keep tube tightly closed when not in use. Protect from excessive heat and direct sunlight. Keep out of reach of children and pets. Discard any unused medication after completion of treatment course. Do not use after the expiration date printed on the packaging. Do not transfer cream to other containers as this may compromise stability and sterility.

Disclaimer

This information is provided for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new medication. Individual results may vary. Proper diagnosis by a healthcare provider is essential before beginning treatment. The manufacturer is not responsible for misuse or incorrect application. Patients should read the package insert thoroughly before use and report any adverse reactions to their healthcare provider.

Reviews

Clinical studies demonstrate that early application of Zovirax Cream reduces healing time by approximately 0.5-1 day compared to placebo. Patients report satisfaction with the reduction in pain duration and lesion size. Dermatologists consistently recommend timely application for optimal results. Some users note the importance of early application during the prodromal phase for maximum effectiveness. The cream formulation is generally well-tolerated with minimal adverse effects. Healthcare providers emphasize that it is not a cure but an effective management option for symptomatic outbreaks.