Viagra: Clinically Proven Erectile Dysfunction Treatment
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Synonyms | |||
Similar products
Viagra (sildenafil citrate) is a prescription phosphodiesterase type 5 (PDE5) inhibitor, representing a first-line pharmacological intervention for the management of erectile dysfunction (ED). Developed through rigorous clinical research, it facilitates blood flow to the penile corpora cavernosa, enabling a physiological erection sufficient for sexual intercourse following sexual stimulation. Its efficacy and safety profile are well-established through extensive global use and numerous peer-reviewed studies.
Features
- Active pharmaceutical ingredient: Sildenafil citrate
- Available in oral tablet formulations: 25 mg, 50 mg, and 100 mg strengths
- Rapid onset of action, typically within 30 to 60 minutes post-administration
- Duration of therapeutic effect persists for up to 4 to 5 hours
- Requires sexual stimulation for efficacy; not an aphrodisiac
Benefits
- Achieves and sustains erections adequate for satisfactory sexual performance
- Improves overall sexual satisfaction and intimacy for patients and their partners
- Enhances self-confidence and reduces anxiety associated with sexual performance
- Supported by over two decades of clinical evidence and real-world use
- Offers flexible dosing to accommodate individual patient response and tolerability
- Can be used on an as-needed basis, providing spontaneity in sexual activity
Common use
Viagra is indicated for the treatment of erectile dysfunction in adult males. Erectile dysfunction is defined as the consistent or recurrent inability to attain and/or maintain a penile erection sufficient for satisfactory sexual performance. It is used by patients with various underlying etiologies of ED, including vasculogenic, neurogenic, and psychogenic causes, as well as mixed or idiopathic origins. It is not indicated for use in women, children, or adolescents.
Dosage and direction
The recommended starting dose for most patients is 50 mg taken orally approximately one hour before anticipated sexual activity. Based on efficacy and tolerability, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. Dosing may be adjusted by a healthcare provider based on individual patient factors, including age, concomitant medications, and underlying health conditions. The tablet should be swallowed whole with a glass of water; it may be taken with or without food, though a high-fat meal may delay the onset of action. The maximum recommended dosing frequency is once per day.
Precautions
Prior to initiation of therapy, a thorough medical and cardiovascular assessment is recommended to ensure the patient is healthy enough for sexual activity. Use with caution in patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie’s disease) or conditions predisposing them to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia). Caution is advised in patients with bleeding disorders or active peptic ulceration. Patients should be advised to seek immediate medical attention if an erection persists for more than 4 hours. Not intended for use by men for whom sexual activity is inadvisable due to underlying cardiovascular status.
Contraindications
Concomitant administration with any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors in any form is absolutely contraindicated due to the risk of profound hypotension. Contraindicated in patients with a known hypersensitivity to sildenafil or any excipient of the formulation. Its use is contraindicated in patients with severe hepatic impairment (Child-Pugh class C), severe hypotension (BP <90/50 mmHg), recent stroke or myocardial infarction, or unstable angina. Concomitant use with riociguat is contraindicated.
Possible side effects
The most commonly reported adverse reactions are headache, flushing, dyspepsia, nasal congestion, and visual disturbances (such as altered color vision, blurred vision, or increased sensitivity to light). These are typically mild to moderate in severity and transient. Less frequently reported side effects include dizziness, rash, and myalgia. Priapism (a prolonged and painful erection lasting more than 4 hours) is a rare but serious adverse event requiring immediate medical intervention to prevent permanent tissue damage. Sudden decrease or loss of hearing, sometimes accompanied by tinnitus and dizziness, has been reported in temporal association with PDE5 inhibitor use. Non-arteritic anterior ischemic optic neuropathy (NAION) has been reported rarely.
Drug interaction
Concomitant use with nitrates is contraindicated. Potent inhibitors of cytochrome P450 3A4 (e.g., ketoconazole, itraconazole, ritonavir, erythromycin, clarithromycin) may increase sildenafil plasma concentrations; a starting dose of 25 mg should be considered. Alpha-blockers (e.g., doxazosin, tamsulosin) may potentiate the blood-pressure-lowering effects; concomitant administration should be undertaken with caution and only when the patient is on a stable alpha-blocker regimen. Inducers of CYP3A4 (e.g., rifampin, carbamazepine, phenytoin, St. John’s Wort) may decrease sildenafil concentrations. Grapefruit juice may increase plasma levels of sildenafil and should be avoided.
Missed dose
Viagra is not intended for chronic daily dosing and is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. The medication should simply be taken approximately one hour before the next anticipated sexual activity, adhering to the maximum once-daily dosing frequency.
Overdose
In cases of overdose exceeding the maximum recommended dose, the adverse event profile would be expected to be an extension of those seen at recommended doses. Supportive measures should be employed, including maintaining blood pressure and vital signs. Since sildenafil is highly protein-bound, it is not expected to be dialyzable. Standard supportive care is the mainstay of treatment for overdose.
Storage
Store at room temperature between 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F). Keep the medication in its original container to protect from light and moisture. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Viagra is a prescription medication. A healthcare professional must diagnose erectile dysfunction and determine the appropriateness of this treatment based on an individual’s specific health profile. Always follow the dosage and instructions provided by your prescribing physician. Do not share your medication with others.
Reviews
“After a prostatectomy, I experienced significant ED. My urologist prescribed Viagra. The 50mg dose has reliably restored my ability to have satisfactory intercourse. The side effect of mild flushing is noticeable but manageable.” — Verified Patient, 62
“As a cardiologist, I carefully evaluate my patients before considering PDE5 inhibitors. For appropriate candidates with stable cardiovascular disease, Viagra remains a highly effective and well-tolerated option that significantly improves quality of life.” — Dr. Evans, Cardiologist
“The consistency and predictability of Viagra’s effect have been crucial for managing my performance anxiety. Taking it about an hour beforehand allows for a natural and spontaneous experience.” — Verified Patient, 48
“Extensive post-marketing surveillance and clinical data continue to support the positive benefit-risk profile of sildenafil for the vast majority of men with erectile dysfunction.” — Clinical Pharmacologist Review
“I tried a lower dose initially but found the 100mg strength provided the most reliable response for me. I experience some nasal congestion, but the benefit far outweighs this minor inconvenience.” — Verified Patient, 55