Trandate: Expert Dual-Action Blood Pressure Control
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.63 | $49.02 (0%) | 🛒 Add to cart |
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Synonyms | |||
Trandate (labetalol hydrochloride) is a prescription medication combining alpha- and beta-adrenergic blocking actions, designed for the effective management of hypertension. It offers a unique mechanism that reduces peripheral vascular resistance without significantly affecting cardiac output, making it a versatile choice in clinical practice. This agent is particularly valued in scenarios requiring rapid yet controlled blood pressure reduction, including hypertensive emergencies and perioperative settings. Its balanced pharmacological profile supports both acute and long-term cardiovascular stability, aligning with modern therapeutic goals of precision and safety.
Features
- Contains labetalol hydrochloride as the active ingredient
- Available in tablet and injectable formulations for flexible administration
- Exhibits combined non-selective beta-blocking and selective alpha1-blocking properties
- Onset of action within 2 hours for oral tablets; rapid effect with IV formulation
- Metabolism occurs primarily in the liver, with renal excretion of metabolites
- Compatible with various antihypertensive regimens for combination therapy
Benefits
- Provides dual-action blood pressure control through complementary adrenergic blockade
- Maintains cardiac output and organ perfusion while reducing afterload
- Minimizes reflex tachycardia commonly associated with pure vasodilators
- Suitable for use in a broad patient population, including some with comorbid conditions
- Offers both immediate-release and extended options for tailored treatment plans
- Supports long-term cardiovascular risk reduction when used as prescribed
Common use
Trandate is indicated for the management of hypertension, both as monotherapy and in combination with other antihypertensive agents. It is also employed in the treatment of hypertensive emergencies, where rapid blood pressure control is required. Clinicians may select it for perioperative hypertension management, particularly in settings where fluctuations in blood pressure must be carefully moderated. Off-label uses include the management of preeclampsia and certain cases of pheochromocytoma, under specialist supervision.
Dosage and direction
For hypertension, the initial oral dose is typically 100 mg twice daily, which may be titrated upward at intervals of 2–3 days based on therapeutic response. Maintenance doses range from 200–800 mg daily, divided into two doses. The maximum recommended daily dose is 2400 mg. For intravenous administration in hypertensive emergencies, an initial bolus of 20 mg is given, followed by incremental doses of 40–80 mg every 10 minutes as needed, up to a total cumulative dose of 300 mg. Continuous infusion may be initiated at 2 mg/min and titrated to effect. Always follow specific clinical protocols and adjust for hepatic or renal impairment.
Precautions
Use with caution in patients with a history of heart failure, bronchospastic disease, diabetes, or hepatic impairment. May mask signs of hypoglycemia or hyperthyroidism. Abrupt discontinuation should be avoided due to risk of rebound hypertension. Monitor renal function and electrolytes periodically. Caution is advised when administering to elderly patients due to potential increased sensitivity. Patients should be advised against operating machinery or driving until their response to therapy is established.
Contraindications
Trandate is contraindicated in patients with bronchial asthma, overt cardiac failure, cardiogenic shock, severe bradycardia, heart block greater than first degree, and hypersensitivity to any component of the formulation. Should not be used in conditions associated with severe and prolonged hypotension.
Possible side effect
Common adverse reactions include dizziness, fatigue, nausea, and tingling of the scalp or skin. Orthostatic hypotension may occur, particularly at initiation of therapy or with dose escalation. Less frequently, bronchospasm, heart failure, bradycardia, and rash have been reported. Hepatic injury, though rare, has been observed and should be monitored. Most side effects are dose-dependent and often diminish with continued use or dose adjustment.
Drug interaction
Concomitant use with other antihypertensive agents may potentiate blood pressure-lowering effects. Caution is required with verapamil or diltiazem due to additive effects on cardiac conduction. May enhance the hypoglycemic effects of insulin and oral antidiabetic drugs. Concurrent use with catecholamine-depleting agents (e.g., reserpine) may produce excessive reduction of sympathetic nervous activity. NSAIDs may diminish the antihypertensive efficacy. Always review the full medication profile before initiation.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling up on doses is not recommended due to the risk of excessive hypotension or bradycardia.
Overdose
Overdose may manifest as severe hypotension, bradycardia, bronchospasm, or cardiac failure. Management includes close monitoring of vital signs, ECG, and blood glucose. Administer IV fluids for hypotension; atropine may be used for bradycardia. Beta-agonist bronchodilators are indicated for bronchospasm. In severe cases, glucagon administration may be considered. Hemodialysis is not effective due to high protein binding.
Storage
Store at room temperature (15–30°C or 59–86°F) in a tightly closed container, protected from light and moisture. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging.
Disclaimer
This information is intended for healthcare professionals and should not replace personalized medical advice. Prescribing decisions must be based on the individual patient’s clinical status, contraindications, and current treatment guidelines. Always consult the full prescribing information before initiating therapy.
Reviews
Clinical studies and post-marketing surveillance support the efficacy and tolerability of Trandate in diverse patient populations. It is frequently noted for its rapid action in critical settings and reliable performance in chronic hypertension management. Many experts appreciate its hemodynamic profile, which offers a balance between efficacy and physiological stability. Long-term user reports often highlight improved blood pressure control with a manageable side effect profile when dosed appropriately.