Seroflo Inhaler: Advanced Dual-Action Asthma and COPD Control
| Product dosage: 250mcg | |||
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| 8 | $70.84
Best per inhaler | $756.80 $566.74 (25%) | 🛒 Add to cart |
Synonyms | |||
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Seroflo Inhaler represents a significant advancement in the management of obstructive airway diseases, combining two established therapeutic agents into a single, convenient device. This fixed-dose combination inhaler is designed for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) in patients requiring both an inhaled corticosteroid (ICS) and a long-acting beta2-agonist (LABA). Its formulation is engineered to provide superior anti-inflammatory and bronchodilatory effects, improving lung function, reducing exacerbation frequency, and enhancing overall quality of life. By simplifying complex medication regimens, Seroflo promotes better adherence and offers a streamlined approach to achieving long-term respiratory stability.
Features
- Fixed-dose combination of Fluticasone Propionate (an inhaled corticosteroid) and Salmeterol Xinafoate (a long-acting beta2-agonist).
- Available in multiple strength configurations (e.g., Seroflo 100, Seroflo 250) to allow for personalized dose titration.
- Delivered via a pressurized Metered-Dose Inhaler (pMDI) device for consistent and reliable dosing.
- Each actuation delivers a precise, pre-measured dose of medication directly to the lungs.
- Designed with a dose counter to monitor the number of inhalations remaining, ensuring patients do not run out of medication unexpectedly.
- Formulated with hydrofluoroalkane (HFA) as a propellant, which is chlorofluorocarbon (CFC)-free and environmentally safer.
Benefits
- Dual-Mechanism Control: Simultaneously addresses both airway inflammation (through the corticosteroid) and bronchoconstriction (through the bronchodilator) for comprehensive disease management.
- Reduced Exacerbation Risk: Clinically proven to significantly decrease the frequency and severity of asthma attacks and COPD flare-ups, leading to fewer emergency room visits and hospitalizations.
- Improved Lung Function: Promotes sustained bronchodilation, leading to better FEV1 (Forced Expiratory Volume in 1 second) scores and enhanced ability to perform daily activities.
- Simplified Treatment Regimen: Combining two medications into one inhaler reduces the number of daily inhalations, minimizing complexity and improving patient adherence to prescribed therapy.
- Symptom Relief: Provides 24-hour control of wheezing, shortness of breath, and chest tightness, enabling a more active and unrestricted lifestyle.
- Preventative Action: Regular use helps to control underlying inflammation, preventing symptoms from occurring rather than just providing rescue relief.
Common use
Seroflo Inhaler is indicated for the regular maintenance treatment of:
- Asthma: In patients where a combination product is appropriate, specifically those not adequately controlled on inhaled corticosteroids and “as-needed” short-acting beta2-agonists, or those already controlled on both an inhaled corticosteroid and a long-acting beta2-agonist.
- Chronic Obstructive Pulmonary Disease (COPD): For the symptomatic treatment of patients with severe COPD (FEV1 < 50% predicted normal) and a history of repeated exacerbations, who have significant symptoms despite regular bronchodilator therapy.
It is crucial to understand that Seroflo is not indicated for the relief of acute bronchospasm. Patients must have a separate, fast-acting rescue inhaler (e.g., salbutamol) for immediate symptom relief.
Dosage and direction
The dosage must be individualized based on disease severity and prior therapy. The following is general guidance; the prescribing physician’s instructions must always be followed precisely.
- For Asthma:
- Adults and adolescents (12 years and older): The recommended starting dose is typically one or two inhalations twice daily. Common strengths include Seroflo 100 (50 mcg salmeterol/100 mcg fluticasone per inhalation) or Seroflo 250 (50 mcg salmeterol/250 mcg fluticasone per inhalation). The dose may be titrated to the lowest dose at which effective control of symptoms is maintained.
- Children (4-11 years): A lower strength, such as Seroflo 50 (50 mcg salmeterol/50 mcg fluticasone per inhalation), may be used. The dose is usually one inhalation twice daily.
- For COPD:
- Adults: The recommended dose is two inhalations of Seroflo 250 twice daily.
Directions for Use:
- Remove the mouthpiece cover and check the interior for foreign objects.
- Shake the inhaler well for 5 seconds.
- Breathe out fully, away from the inhaler.
- Place the mouthpiece between your teeth and close your lips around it firmly.
- Just after you start to breathe in slowly and deeply through your mouth, press down firmly on the canister to release one puff of medication.
- Continue to breathe in slowly and hold your breath for about 10 seconds, or for as long as is comfortable.
- Breathe out slowly.
- Wait about 30 seconds before repeating steps 2-7 for a second inhalation if prescribed.
- Rinse your mouth with water and spit it out after each use to help prevent oral thrush (candidiasis) and hoarseness.
Precautions
- Paradoxical Bronchospasm: Seroflo can produce life-threatening paradoxical bronchospasm (immediate wheezing and shortness of breath after dosing). If this occurs, treatment should be discontinued immediately and alternative therapy instituted.
- Cardiovascular Effects: Salmeterol, a component of Seroflo, can produce clinically significant cardiovascular effects in some patients, such as increases in pulse rate and blood pressure. Use with caution in patients with cardiovascular disorders (e.g., coronary insufficiency, cardiac arrhythmias, hypertension).
- Systemic Corticosteroid Effects: While fluticasone has a favorable safety profile, high doses of inhaled corticosteroids absorbed into the bloodstream can potentially lead to systemic effects, including hypercorticism, adrenal suppression, growth retardation in children and adolescents, decreased bone mineral density, cataracts, and glaucoma. Patients should be monitored for these effects.
- Immunosuppression: Patients on corticosteroid therapy may have reduced immunity and should be warned to avoid exposure to infections like chickenpox or measles. If exposed, medical advice should be sought promptly.
- Hypokalemia and Hyperglycemia: Beta2-agonists, including salmeterol, may produce significant hypokalemia (low potassium levels) and hyperglycemia (high blood sugar) in some patients, especially at high doses. This is particularly important to monitor in patients with severe asthma and diabetes.
- Osteoporosis: Patients at risk for osteoporosis should be monitored, and bone mineral density should be considered if long-term high-dose therapy is used.
Contraindications
Seroflo Inhaler is contraindicated in patients with:
- A known hypersensitivity to fluticasone propionate, salmeterol xinafoate, or any other ingredient in the formulation.
- Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.
- Significant, severe cardiovascular disorders where a beta2-agonist would be inappropriate.
Possible side effects
Like all medicines, Seroflo can cause side effects, although not everybody gets them.
Very Common (may affect more than 1 in 10 people):
- Headache.
Common (may affect up to 1 in 10 people):
- Oral candidiasis (fungal infection in the mouth, or “thrush”).
- Hoarseness or dysphonia.
- Throat irritation.
- Palpitations (awareness of heartbeat).
- Tremor.
- Muscle cramps.
- Nausea and vomiting.
- Cough.
Uncommon (may affect up to 1 in 100 people):
- Skin reactions (rash, dermatitis).
- Anxiety, sleep disturbances, restlessness.
- Tachycardia (fast heart rate).
- Bruising.
- Cataracts, glaucoma.
Rare (may affect up to 1 in 1,000 people):
- Anaphylactic reactions (severe allergy).
- Angioedema (swelling, particularly of the face and throat).
- Psychiatric effects such as depression or behavioral changes (primarily reported in children).
- Paradoxical bronchospasm.
Patients should report any unusual or severe side effects to their doctor immediately.
Drug interaction
Inform your doctor about all medicines you are taking, including prescription, over-the-counter, and herbal products.
- Beta-blockers: Non-selective beta-blockers (e.g., propranolol) can antagonize the bronchodilatory effect of beta2-agonists like salmeterol and may produce severe bronchospasm in asthmatic patients. Cardioselective beta-blockers should be used with caution.
- Diuretics: Concomitant use of non-potassium-sparing diuretics (e.g., furosemide, thiazides) can potentiate the hypokalemic effect of beta2-agonists.
- CYP3A4 Inhibitors: Potent inhibitors of the cytochrome P450 3A4 enzyme (e.g., ketoconazole, ritonavir, clarithromycin) can increase systemic exposure to fluticasone, increasing the risk of systemic corticosteroid side effects. Co-administration should be avoided unless the benefit outweighs the increased risk.
- Other Sympathomimetics: Concurrent use with other beta-adrenergic drugs (e.g., other LABAs, decongestants) may potentiate the sympathetic effects of salmeterol, leading to adverse cardiovascular effects.
- Xanthine Derivatives: Concomitant administration with theophylline may potentiate the hypokalemic effect of salmeterol.
- MAOIs and Tricyclic Antidepressants: These can potentiate the cardiovascular effects of beta-agonists.
Missed dose
- If a dose is missed, it should be taken as soon as it is remembered.
- However, if it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.
- Do not take a double dose to make up for a forgotten one.
- Maintaining a regular schedule is important for optimal control of your condition.
Overdose
- Overdose of Salmeterol: May be expected to produce effects typical of excessive beta-adrenergic stimulation: tachycardia, arrhythmias, tremor, headache, muscle cramps, hypertension, hypokalemia, and hyperglycemia. Cardiac arrest and even death may occur.
- Overdose of Fluticasone: Acute overdose is unlikely. During chronic overdose, systemic corticosteroid effects such as hypercorticism and adrenal suppression may appear.
- Management: Treatment consists of discontinuation of Seroflo together with institution of appropriate symptomatic and supportive therapy. The use of a cardioselective beta-receptor blocker may be considered, but only with extreme caution in patients with a history of asthma.
Storage
- Store at room temperature (15°C to 30°C). Do not freeze.
- Keep the canister away from direct sunlight, heat, and open flame. Do not puncture or incinerate, even when apparently empty.
- Keep out of the sight and reach of children.
- The inhaler is packaged in a foil pouch to protect it from moisture and should be used immediately after opening the pouch.
- Note the expiration date on the canister and packaging. Do not use after this date.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is based on standard prescribing guidelines and may not encompass all possible uses, directions, precautions, or interactions.
Reviews
- Clinical Consensus: Seroflo is widely regarded by pulmonologists as a cornerstone of maintenance therapy for moderate-to-severe asthma and COPD. Its efficacy in improving lung function parameters (FEV1) and reducing exacerbation rates is well-documented in numerous large-scale clinical trials.
- Patient Feedback: Many patients report a significant improvement in their quality of life, noting fewer nighttime symptoms, reduced reliance on rescue medication, and an increased ability to engage in physical activity. The convenience of a combination inhaler is frequently cited as a major benefit for adherence.
- Noted Considerations: The most commonly reported drawbacks from patient reviews are the potential for oral thrush (largely preventable with proper rinsing) and the hoarseness that can sometimes occur. The importance of proper inhaler technique is consistently emphasized by healthcare professionals to maximize efficacy and minimize local side effects.