Pure Ascorbic Acid for Optimal Cellular Health and Immunity
| Product dosage: 60mg | |||
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Synonyms | |||
Ascorbic acid, the pure and scientifically-identified form of Vitamin C, is an essential water-soluble micronutrient critical for numerous physiological functions. Unlike esterified or buffered forms, pharmaceutical-grade L-ascorbic acid offers maximum bioavailability and potency for targeted therapeutic outcomes. Its role extends far beyond general wellness, acting as a potent antioxidant, essential cofactor in collagen synthesis, and crucial component in immune modulation and neurotransmitter production. This monograph provides a comprehensive, evidence-based overview for healthcare professionals considering ascorbic acid in clinical or supplemental contexts.
Features
- Pharmaceutical-grade L-ascorbic acid (≥99.5% purity)
- Water-soluble crystalline powder or tablet form
- Molecular formula: C₆H₈O₆
- Molecular weight: 176.12 g/mol
- Melting point: 190–192°C (with decomposition)
- pH of 1% solution: approximately 2.4–2.8
- Readily oxidizes in air, light, and alkaline conditions
- Synergistic with bioflavonoids for enhanced absorption
Benefits
- Supports robust immune function by enhancing neutrophil and lymphocyte activity
- Promotes collagen biosynthesis for skin, vascular, and connective tissue integrity
- Functions as a potent aqueous-phase antioxidant, neutralizing free radicals
- Enhances non-heme iron absorption through reduction to ferrous state
- Facilitates catecholamine synthesis and carnitine production
- May reduce oxidative stress markers in chronic inflammatory conditions
Common use
Ascorbic acid is indicated for the prevention and treatment of vitamin C deficiency, including scurvy. It is widely utilized as adjunct therapy in wound healing, postoperative recovery, and tissue repair. In immunological contexts, it is employed to support immune response during periods of increased oxidative stress or infection. Dermatological applications include supporting collagen production and photoprotection. It is also commonly used to improve iron absorption in cases of iron-deficiency anemia, particularly with concomitant iron supplementation.
Dosage and direction
Prophylactic dosing: 75–90 mg daily for adults (higher for smokers: +35 mg/day).
Therapeutic dosing: 250–1000 mg daily in divided doses, depending on clinical indication.
Scurvy treatment: 300–1000 mg daily for at least one week, followed by 100–300 mg daily until full recovery.
For enhanced iron absorption: 100–200 mg taken with iron-containing meals.
Administer with water, preferably with or after meals to minimize gastrointestinal discomfort. Divided dosing is recommended for doses exceeding 500 mg to maintain steady plasma concentrations and enhance absorption efficiency. Maximum intestinal absorption occurs at single doses of 200–400 mg; higher doses result in decreased fractional absorption and increased urinary excretion.
Precautions
Monitor patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to risk of hemolysis with high doses. Use caution in patients with history of calcium oxalate kidney stones, as ascorbic acid is metabolized to oxalate. High doses may cause gastrointestinal disturbances; titrate gradually in sensitive individuals. Long-term excessive intake (＞2 g/day) may lead to dependency and rebound scurvy upon abrupt cessation. Protect from light, moisture, and air to prevent oxidation.
Contraindications
Hypersensitivity to ascorbic acid or any component of the formulation. Contraindicated in patients with hereditary iron overload disorders (e.g., hemochromatosis, thalassemia) due to enhanced iron absorption. Not recommended in severe renal impairment without medical supervision.
Possible side effect
Generally well-tolerated at recommended doses. Adverse effects are typically dose-dependent and include:
- Gastrointestinal disturbances (nausea, abdominal cramps, diarrhea)
- Transient osmotic diuresis with high doses
- Headache or insomnia in sensitive individuals
- Acidification of urine, potentially leading to crystalluria
- Local irritation with intravenous administration
Drug interaction
- Antacids containing aluminum: May increase aluminum absorption
- Aspirin and salicylates: May lower ascorbic acid levels and increase excretion
- Barbiturates and primidone: May enhance ascorbic acid elimination
- Fluphenazine: High-dose vitamin C may reduce serum levels
- Warfarin: Theoretical interaction; monitor INR with high-dose supplementation
- Estrogens: May increase estrogen levels with concomitant use
- Chemotherapeutic agents: Antioxidant effects may interfere with oxidative mechanisms of some agents—consult oncologist
Missed dose
If a dose is missed, take it as soon as remembered. If it is near the time of the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up. Consistency supports maintenance of tissue saturation.
Overdose
Acute toxicity is rare due to efficient renal excretion. Doses exceeding 3 g may cause gastrointestinal distress, including diarrhea and nausea. Massive overdose (＞10 g) could theoretically lead to oxalate nephropathy or renal calculi. Management is supportive; discontinue use and ensure hydration. Hemodialysis may be considered in severe cases, though rarely indicated.
Storage
Store in a tightly closed, light-resistant container at controlled room temperature (15–30°C). Protect from moisture, air, and light. Keep away from alkaline substances and oxidizing agents. Do not store in metal containers. Powder formulations are particularly hygroscopic and require dessicant protection.
Disclaimer
This information is intended for healthcare professionals and educated consumers. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before initiating any new supplement regimen. Dosage and indications may vary based on individual health status and concomitant medications.
Reviews
Dr. Elena Rostova, MD, Internal Medicine: “I routinely recommend pharmaceutical-grade ascorbic acid to my patients with recurrent infections or poor wound healing. The evidence supporting its role in immune function and collagen synthesis is robust. I advise divided dosing for optimal absorption.”
Clinical Nutritionist Mark Thibodeau, RD: “The purity and predictability of ascorbic acid make it my go‐back for targeted supplementation. I combine it with flavonoids for patients with vascular fragility or iron deficiency. Gastrointestinal tolerance is excellent when dosed appropriately.”
Research Pharmacist Dr. Susan Lee, PharmD: “As a compounding pharmacist, I appreciate the stability and versatility of pure ascorbic acid. It remains a cornerstone in IV antioxidant protocols, though we always adjust for renal function and oxidative status.”
Patient (post‐surgical recovery): “My surgeon recommended 500 mg twice daily after my procedure. I noticed significantly improved healing and energy levels without any side effects. I continue using a maintenance dose for immune support.”
Sports Medicine Physician Dr. Alex Rivera: “In athletic populations, we use ascorbic acid to mitigate exercise‐induced oxidative stress and support connective tissue repair. Doses of 500–1000 mg/day are effective without causing dependency.”