Provera (medroxyprogesterone acetate) is a prescription progestin medication used to treat a variety of hormone-related conditions in women. It is a synthetic form of the natural hormone progesterone, designed to address issues such as abnormal uterine bleeding, amenorrhea, and endometrial protection during estrogen replacement therapy. By supplementing or replacing natural progesterone, Provera helps restore hormonal balance, manage menstrual irregularities, and support endometrial health. Its well-established efficacy and extensive clinical history make it a trusted option for gynecologists and healthcare providers worldwide.

Features

• Active ingredient: Medroxyprogesterone Acetate
• Available in 2.5 mg, 5 mg, and 10 mg oral tablets
• Synthetic progestin with high bioavailability
• FDA-approved for multiple gynecological indications
• Standardized manufacturing under strict pharmaceutical controls
• Typically supplied in bottles of 30 or 100 tablets

Benefits

• Regulates menstrual cycles and reduces abnormal uterine bleeding
• Provides endometrial protection against hyperplasia in women using estrogen
• Treats secondary amenorrhea by inducing withdrawal bleeding
• Helps manage symptoms of endometriosis in some patients
• Offers predictable hormonal activity with established dosing protocols
• Supported by decades of clinical use and research data

Common use

Provera is commonly prescribed for several gynecological conditions. It is frequently used to treat abnormal uterine bleeding caused by hormonal imbalance without organic pathology. For women experiencing secondary amenorrhea (absence of menstrual periods), Provera is administered to induce withdrawal bleeding and help reestablish regular cycles. In menopausal women receiving estrogen therapy, Provera is added cyclically to protect the endometrium from hyperplasia that can result from unopposed estrogen exposure. Some healthcare providers may also prescribe it off-label for endometriosis management or as part of certain fertility treatment protocols.

Dosage and direction

Dosage varies significantly based on the condition being treated and individual patient factors. For abnormal uterine bleeding: 5-10 mg daily for 5-10 days beginning on day 16 of cycle. For secondary amenorrhea: 5-10 mg daily for 5-10 days. For endometrial protection with estrogen therapy: typically 5-10 mg daily for 12-14 days per month. Tablets should be taken at approximately the same time each day, with or without food. Patients should follow their healthcare provider’s specific instructions regarding timing, duration, and cyclic administration. Treatment typically begins on specific days of the menstrual cycle as directed.

Precautions

Patients should undergo thorough medical evaluation before starting Provera. Regular monitoring of blood pressure, weight, and clinical response is recommended. Use with caution in patients with conditions that might be influenced by fluid retention, such as epilepsy, migraine, asthma, or cardiac or renal dysfunction. Patients with a history of depression should be closely monitored as progesterone can exacerbate symptoms. Provera may cause dizziness or drowsiness; patients should exercise caution when operating machinery or driving until they know how the medication affects them. Mammograms and breast examinations should be performed as recommended based on age and risk factors.

Contraindications

Provera is contraindicated in patients with known hypersensitivity to medroxyprogesterone acetate or any component of the formulation. It should not be used in women with known or suspected pregnancy, as it may cause harm to the fetus. Other contraindications include known or suspected breast cancer, active thrombophlebitis, current or past history of thromboembolic disorders, cerebral vascular disease, liver dysfunction or disease, undiagnosed abnormal genital bleeding, and missed abortion. It is also contraindicated in patients with known progesterone-dependent neoplasms.

Possible side effect

Common side effects may include breakthrough bleeding, spotting, changes in menstrual flow, amenorrhea, breast tenderness or discomfort, nausea, bloating, headache, dizziness, fatigue, weight changes, and acne. Less frequently reported side effects include insomnia, jaundice, allergic reactions, hives, hair loss or growth, changes in libido, depression, nervousness, and rash. Although rare, serious side effects can include thrombophlebitis, pulmonary embolism, retinal thrombosis, cerebral thrombosis, and optic neuritis. Any unusual or severe symptoms should be reported to a healthcare provider immediately.

Drug interaction

Provera may interact with several medications. Aminoglutethimide may significantly decrease medroxyprogesterone acetate levels. Drugs that induce hepatic enzymes (such as rifampin, barbiturates, carbamazepine, phenytoin, and St. John’s Wort) may increase metabolism of Provera, reducing its effectiveness. Progestins may decrease the effectiveness of bromocriptine. Provera may affect blood glucose levels, potentially requiring adjustment of antidiabetic medications. It may also alter thyroid function test results without affecting thyroid function. Patients should inform their healthcare provider of all medications, including over-the-counter drugs and supplements.

Missed dose

If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. Doubling up on doses is not recommended. For cyclic administration regimens, patients should contact their healthcare provider for guidance if they miss doses, as timing is critical for proper hormonal regulation. Consistent adherence to the prescribed schedule is important for optimal therapeutic effect.

Overdose

Acute overdose with Provera is unlikely to cause serious symptoms, though nausea and vomiting may occur. There is no specific antidote for medroxyprogesterone acetate overdose. Treatment should be symptomatic and supportive. In cases of massive overdose, gastric lavage may be considered if performed soon after ingestion. Medical attention should be sought if concerning symptoms develop or if large quantities have been ingested. Chronic overdose may manifest as intensified side effects, particularly related to hormonal effects.

Storage

Store at room temperature (20-25°C or 68-77°F) in a dry place protected from light and moisture. Keep the container tightly closed. Do not store in bathroom areas where moisture levels may be high. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly discard any unused medication after treatment completion according to local guidelines for medication disposal.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Provera is a prescription medication that should be used only under the supervision of a qualified healthcare provider. Individual results may vary. Patients should not start, stop, or change dosage without consulting their healthcare provider. The complete prescribing information should be consulted before use. This information may not include all possible uses, directions, precautions, interactions, or adverse effects.

Reviews

Clinical studies and patient experiences generally reflect Provera’s effectiveness in regulating menstrual cycles and managing abnormal uterine bleeding. Many healthcare providers appreciate its predictable action and established safety profile when used appropriately. Some patients report satisfactory resolution of their symptoms with minimal side effects, while others may experience side effects that lead to discontinuation. The medication receives particular praise for its role in endometrial protection during hormone replacement therapy. As with any hormonal treatment, individual responses vary considerably based on numerous factors including dosage, indication, and patient characteristics.