Prilox Cream: Effective Topical Anesthetic for Rapid Pain Relief
| Product dosage: 5g | |||
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| 10 | $15.82
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Prilox Cream is a topical anesthetic formulation designed for rapid and effective dermal analgesia. It combines two established local anesthetics—lidocaine and prilocaine—in a eutectic mixture that enhances skin penetration and onset of action. This cream is widely used in dermatological, cosmetic, and minor surgical procedures to minimize patient discomfort. Its efficacy, safety profile, and ease of application make it a preferred choice among healthcare professionals for superficial anesthesia.
Features
- Contains lidocaine 2.5% and prilocaine 2.5% in a eutectic mixture
- White, oil-in-water emulsion cream for easy application
- Rapid onset of action, typically within 60 minutes under occlusion
- Provides superficial anesthesia to a depth of up to 3–5 mm
- Single-use sachets and tubes available in various sizes (5g to 30g)
- Stable at room temperature; does not require refrigeration
Benefits
- Significantly reduces pain associated with needle insertions, laser treatments, and superficial surgeries
- Minimizes patient anxiety and improves cooperation, especially in pediatric and sensitive populations
- Non-invasive alternative to injectable anesthetics for suitable procedures
- Allows for pain-free superficial skin interventions, enhancing patient comfort and satisfaction
- Reduces the need for systemic analgesics or sedatives in minor outpatient settings
- Short procedure preparation time with predictable and consistent anesthetic effect
Common use
Prilox Cream is indicated for topical anesthesia on intact skin in adults and children. It is commonly used prior to venipuncture, intravenous cannulation, laser hair removal, superficial dermatological procedures (e.g., cryotherapy, curettage, biopsy), and cosmetic interventions such as tattoo removal or filler injections. It may also be applied before minor surgical procedures including split-thickness skin grafting and laser‐assisted tattoo removal.
Dosage and direction
Apply a thick layer of Prilox Cream (approximately 1–2 g per 10 cm² of skin) to the target area. Cover with an occlusive dressing (e.g., Tegaderm™ or plastic wrap) to enhance absorption. For adults: Apply at least 60 minutes before the procedure. For children: Apply for 60 minutes under strict medical supervision. Do not apply to larger areas or for longer durations than recommended. After the desired application time, remove the cream and cleanse the area. Maximum application area and time should be strictly adhered to based on patient age and clinical context.
Precautions
- For external use only; avoid contact with eyes or mucous membranes.
- Do not apply to broken, inflamed, or diseased skin.
- Use with caution in patients with impaired hepatic function, as systemic absorption may occur.
- Monitor for signs of systemic absorption in patients with conditions that may enhance percutaneous uptake (e.g., eczema, psoriasis).
- Not recommended for use on genital mucosa or for circumcision in infants under 3 months of age.
- Keep out of reach of children.
Contraindications
- Hypersensitivity to lidocaine, prilocaine, other local anesthetics of the amide type, or any component of the formulation.
- Patients with congenital or idiopathic methemoglobinemia.
- Application to mucous membranes or near the eyes.
- Infants under the age of 12 months receiving treatment with methemoglobin-inducing agents.
Possible side effect
Common side effects are usually mild and localized, including:
- Pallor, redness, or edema at the application site
- Transient burning or itching sensation
Rare systemic effects (due to excessive absorption) may include:
- Methemoglobinemia (symptoms: cyanosis, dizziness, dyspnea)
- Allergic reactions (rash, urticaria, anaphylaxis in susceptible individuals)
- Central nervous system effects (headache, nervousness, drowsiness, tremor)
- Cardiovascular effects (bradycardia, hypotension)
Drug interaction
- Concomitant use with other local anesthetics may increase the risk of systemic toxicity.
- Drugs that induce methemoglobinemia (e.g., sulfonamides, nitrates, antimalarials) may increase the risk when used with Prilox Cream.
- CYP3A4 inhibitors (e.g., ketoconazole) may increase plasma levels of lidocaine and prilocaine.
Missed dose
Not applicable, as Prilox Cream is used as a single pre-procedure application. If the cream is accidentally removed or not applied for the full duration, reapply if time permits, or consider alternative analgesia.
Overdose
Excessive application or prolonged exposure may lead to systemic absorption. Symptoms may include CNS excitation or depression (e.g., convulsions, respiratory arrest) and cardiovascular collapse. Methemoglobinemia may occur, particularly in infants and young children. Treatment is supportive; manage symptoms and provide oxygen. Methylene blue may be administered for methemoglobinemia under medical supervision.
Storage
Store at room temperature (15–30°C). Do not freeze. Keep in the original container, tightly closed. Protect from light and moisture. Discard any unused cream after single use; do not reuse.
Disclaimer
This information is intended for healthcare professionals. Always follow national guidelines and prescribing information. Use only as directed. The patient should be informed about proper use and potential side effects. Not for self-medication.
Reviews
Prilox Cream is highly regarded in clinical settings for its efficacy and reliability. Dermatologists and anesthesiologists frequently report high patient satisfaction due to reduced procedural pain. Studies confirm its effectiveness in minimizing discomfort during laser procedures, venipuncture, and superficial surgeries. Some users note that proper occlusion is critical for optimal effect. Rare cases of methemoglobinemia have been reported, primarily in infants, underscoring the importance of adhering to age-specific guidelines.