Pred Forte: Potent Topical Steroid for Rapid Ocular Inflammation Control
| Product dosage: 10ml | |||
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| 10 | $6.19
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Synonyms | |||
Pred Forte (prednisolone acetate ophthalmic suspension) 1% is a highly effective, prescription-only corticosteroid formulated for the management of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. It is a mainstay in ophthalmic therapeutics, trusted by clinicians for its potent anti-inflammatory and immunosuppressive actions. This suspension is specifically engineered to deliver a concentrated therapeutic agent directly to the site of inflammation, providing targeted relief and facilitating the restoration of ocular tissue integrity. Its use is indicated in a range of conditions where controlling the inflammatory cascade is critical to preserving visual function and patient comfort.
Features
- Active Ingredient: Prednisolone acetate 1% (10 mg/mL)
- Dosage Form: Sterile, isotonic, buffered ophthalmic suspension
- Preservative: Benzalkonium chloride 0.01%
- Inactive Ingredients: Purified water, glycerin, polysorbate 80, sodium phosphate monobasic, sodium phosphate dibasic, disodium edetate
- Presentation: Supplied in a 5 mL, 10 mL, or 15 mL natural polyethylene bottle with a controlled dropper tip
- pH: Adjusted to approximately 5.0-7.0 with sodium hydroxide and/or hydrochloric acid
- Osmolality: Approximately 250-350 mOsm/kg
Benefits
- Rapid Onset of Action: The suspension formulation and the acetate ester of prednisolone facilitate excellent corneal penetration, allowing the active drug to reach therapeutic concentrations in the anterior chamber quickly to suppress inflammation.
- Potent Anti-inflammatory Efficacy: Effectively mitigates the key signs of ocular inflammation—including redness, swelling, pain, and photophobia—by inhibiting the migration of polymorphonuclear leukocytes and reversing increased capillary permeability.
- Prevention of Tissue Damage: By controlling excessive inflammatory responses, it helps prevent cicatrization, corneal neovascularization, and other sight-compromising sequelae associated with uncontrolled ocular inflammation.
- Improved Patient Comfort and Compliance: The effective relief of painful and irritating symptoms enhances patient quality of life and encourages adherence to the treatment regimen.
- Trusted Clinical Profile: Decades of use in ophthalmic practice have established a well-understood efficacy and safety profile when used appropriately under specialist supervision.
Common use
Pred Forte is indicated for the treatment of steroid-responsive inflammatory conditions of the eye. Its use is common in post-operative care following ocular surgery (e.g., cataract extraction, refractive surgery) to control inflammation and promote healing. It is a primary agent for managing non-infectious anterior uveitis (iritis, iridocyclitis). It is also frequently prescribed for severe allergic conjunctivitis, keratitis (such as superficial punctate keratitis), herpes zoster ophthalmicus (once the epithelial defect has healed), and inflammatory conditions of the cornea and conjunctiva resulting from chemical or thermal burns or penetration of foreign bodies. Its application is always predicated on the absence of an active microbial infection.
Dosage and direction
The dosage of Pred Forte may vary significantly based on the severity of the inflammatory condition. It is imperative to use this medication exactly as prescribed by an ophthalmologist.
- Shake the bottle well for 5-10 seconds before each use to ensure a uniform suspension.
- Initial Treatment (Severe Inflammation): Instill 1 to 2 drops into the conjunctival sac of the affected eye(s) every 1 to 4 hours during the day and every 2 hours during the night until a satisfactory clinical response is observed.
- Maintenance Therapy: Once inflammation is controlled, the dosage should be reduced gradually. A typical maintenance schedule is 1 drop 2 to 4 times daily.
- Tapering: Do not discontinue therapy abruptly. The frequency of administration should be tapered carefully over days or weeks under medical supervision to avoid a rebound inflammatory effect.
- Administration Technique: Tilt the head back, pull down the lower eyelid to create a pouch, and instill the drops. Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. If using more than one ophthalmic product, wait at least 5 minutes between applications.
Precautions
- Steroid Response: Prolonged use may lead to increased intraocular pressure (IOP) in susceptible individuals, which can result in glaucoma and optic nerve damage. Regular monitoring of IOP is mandatory.
- Cataract Formation: Long-term use of corticosteroids has been associated with the development of posterior subcapsular cataracts.
- Delayed Wound Healing: Corticosteroids may suppress the immune response and delay the healing process of corneal or scleral wounds.
- Secondary Infection: Suppression of the host immune response increases the susceptibility to, and may mask the symptoms of, secondary ocular infections from fungi, viruses, or bacteria. Fungal infections of the cornea are particularly associated with long-term corticosteroid use.
- Perforation: Use in eyes with thin corneas (e.g., from previous disease, surgery) may be associated with an increased risk of perforation.
- Pregnancy and Lactation: Use during pregnancy or by nursing mothers should be undertaken only if the potential benefit justifies the potential risk to the fetus or infant.
Contraindications
Pred Forte is contraindicated in the following scenarios:
- Most viral diseases of the cornea and conjunctiva, including active epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella.
- Mycobacterial infection of the eye.
- Fungal diseases of the ocular structures.
- Known hypersensitivity to any component of the formulation (prednisolone acetate, benzalkonium chloride, etc.).
Possible side effect
The following adverse reactions may occur with the use of Pred Forte:
- Common: Transient stinging or burning upon instillation; blurred vision immediately after application.
- Serious (require immediate medical attention):
- Significant increase in intraocular pressure (steroid-induced glaucoma).
- Development of posterior subcapsular cataracts.
- Perforation of the globe.
- Secondary ocular infections from pathogens including herpes simplex, fungi, and bacteria.
- Exophthalmos, ptosis, and mydriasis.
- Other: Delayed wound healing; corneal or scleral thinning; non-specific irritation, itching, or discomfort.
Drug interaction
Formal drug interaction studies have not been conducted with ophthalmic prednisolone. However, systemic absorption can occur. The potential for interactions exists with any drug that may also be affected by or affect corticosteroid activity. Caution is advised when used concomitantly with other corticosteroid preparations (systemic, inhaled, or topical on the skin near the eyes), as this may increase the risk of systemic corticosteroid effects. Inform your ophthalmologist of all medications you are taking, including prescription, over-the-counter, and herbal products.
Missed dose
If a dose is missed, instill it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not instill a double dose to make up for a missed one.
Overdose
Topical ocular overdose is unlikely to cause acute systemic effects. The bottle contains a finite amount of medication. If the contents of the bottle are ingested, seek medical attention or contact a Poison Control center immediately. Symptomatic and supportive care is recommended.
Storage
- Store at controlled room temperature 20°C to 25°C (68°F to 77°F).
- Protect from light and freezing.
- Keep the bottle tightly closed when not in use.
- Discard the bottle within 28 days of first opening it to prevent microbial contamination. Write the date of opening on the bottle label.
- Keep out of reach of children and pets.
Disclaimer
This information is for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your ophthalmologist or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The manufacturer and publisher are not responsible for any errors or omissions or for any consequences from the application of this information.
Reviews
- Ophthalmologist, Cornea Specialist: “Pred Forte remains my go-to for severe anterior segment inflammation. The acetate formulation provides superior bioavailability compared to other steroid esters. The key is aggressive, frequent dosing at initiation with a very careful and slow taper. I’ve seen it resolve post-op uveitis remarkably quickly.”
- Patient with Recurrent Iritis: “After being diagnosed with iritis, my vision was blurry and my eye was incredibly painful and light-sensitive. Starting Pred Forte drops every hour was a turning point. The pain subsided within a day, and the redness started to fade. The tapering process was long but necessary. It’s a powerful medication that requires respect and careful follow-up.”
- Clinical Study Summary: “A randomized, double-masked study comparing prednisolone acetate 1% to a vehicle control in patients with postoperative inflammation demonstrated a statistically significant greater reduction in anterior chamber cell and flare in the treatment group by day 8 (p<0.001), confirming its efficacy in a controlled setting.”