The HESHE ED Pack represents a clinically-formulated combination therapy designed to address erectile dysfunction through a synergistic pharmacological approach. This pack includes two distinct, FDA-approved phosphodiesterase type 5 (PDE5) inhibitors, allowing for tailored treatment based on individual response, duration of effect, and personal tolerance. By offering flexibility in dosing and onset of action, the HESHE ED Pack enables practitioners and patients to optimize therapeutic outcomes while minimizing potential side effects through informed, physician-guided usage. It is indicated for adult males experiencing erectile dysfunction of various etiologies, providing a reliable and evidence-based option within a structured treatment protocol.

Features

• Contains two different PDE5 inhibitors for versatile dosing
• Includes both short-acting and long-acting formulations
• Pre-measured, blister-packed doses for adherence and safety
• Manufactured in FDA-approved facilities under cGMP
• Clearly labeled with expiration dates and lot numbers
• Accompanied by detailed medical information leaflet

Benefits

• Enables individualized treatment plans based on patient response and needs
• Provides options for both spontaneous and planned sexual activity
• Redensifies erectile response through proven vasodilatory mechanisms
• Enhances sexual confidence and relationship satisfaction
• Supported by extensive clinical research and safety profiles
• Offers cost-effective combination therapy compared to separate prescriptions

Common use

The HESHE ED Pack is commonly prescribed for adult males diagnosed with erectile dysfunction of organic, psychogenic, or mixed etiology. It is particularly useful for patients who may benefit from having multiple pharmacological options available, such as those with variable timing of sexual activity or those who have experienced suboptimal results with single-agent therapy. The pack is often utilized when titration or switching between agents under medical supervision is indicated, providing both immediate and extended-duration options within one treatment package. It is not intended for use by women, adolescents, or men without erectile dysfunction.

Dosage and direction

Dosage must be individualized based on medical evaluation, efficacy, and tolerance. Typically, one tablet is taken approximately 30-60 minutes before anticipated sexual activity, with or without food (though high-fat meals may delay absorption). The short-acting formulation may be taken 4-6 hours apart from the long-acting formulation if switching between doses is necessary. Do not exceed one dose per 24-hour period. Sexual stimulation is required for medication efficacy. Patients should begin with the lowest recommended dose and adjust under physician guidance based on response and side effects.

Precautions

Prior to use, patients must undergo comprehensive medical evaluation to assess cardiovascular health, as sexual activity carries potential cardiac risk. Use with caution in patients with anatomical penile deformity, bleeding disorders, or active peptic ulcer disease. May cause dizziness or visual changes; avoid activities requiring alertness until response is known. Not recommended for use with other erectile dysfunction treatments. Patients should avoid excessive alcohol consumption (may increase risk of hypotension and decrease efficacy). Store out of reach of children and pets.

Contraindications

Absolute contraindications include concomitant use of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate) or nitric oxide donors in any form due to risk of severe hypotension. Contraindicated in patients with known hypersensitivity to any component of the formulation. Not for use in men with cardiac conditions where sexual activity is inadvisable, including unstable angina, recent myocardial infarction, or uncontrolled hypertension. Avoid in patients with severe hepatic impairment (Child-Pugh C) or end-stage renal disease requiring dialysis.

Possible side effects

Common side effects (≥2%) include headache, flushing, dyspepsia, nasal congestion, back pain, myalgia, and visual disturbances (including cyanopsia and photophobia). Less frequently reported effects include dizziness, rash, and palpitations. Rare but serious adverse events include priapism (prolonged erection >4 hours requiring immediate medical attention), sudden hearing loss, non-arteritic anterior ischemic optic neuropathy (NAION), and cardiovascular events. Most side effects are mild to moderate and transient in nature.

Drug interaction

Significant interactions occur with nitrates and alpha-blockers (additive hypotension). Moderate interactions with CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin) may increase exposure—dose adjustment may be necessary. Caution with antihypertensives, alcohol, and grapefruit juice (may increase side effects). Avoid concomitant use with other PDE5 inhibitors. Inform healthcare provider of all medications, including over-the-counter drugs and supplements.

Missed dose

This medication is taken on an as-needed basis rather than a scheduled regimen. If a dose is missed, take it when remembered if sufficient time remains before sexual activity (following the recommended pre-activity timing). Do not double the dose or take more than one tablet within 24 hours. If sexual activity is not anticipated, the missed dose can be omitted without consequence.

Overdose

In case of suspected overdose, seek immediate medical attention or contact a poison control center. Symptoms may include severe headache, profound hypotension, syncope, prolonged erection, and visual disturbances. Supportive measures should be implemented, including supine positioning with legs elevated if hypotensive. Priapism requires urgent urological intervention to prevent permanent tissue damage. Dialysis is not effective due to high protein binding.

Storage

Store at room temperature (15-30°C or 59-86°F) in the original packaging to protect from light and moisture. Keep tightly closed and out of reach of children and pets. Do not use beyond the expiration date printed on the packaging. Do not transfer tablets to other containers, as this may compromise stability and identification.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting, changing, or stopping any medication. The prescribing physician should be aware of the patient’s complete medical history and current medications. Not all possible uses, interactions, or adverse effects are listed here. Proper diagnosis and supervision are essential for safe and effective treatment.

Reviews

“The flexibility of having two options in one pack has been transformative for my patients who travel frequently or have irregular schedules.” — Dr. Evan R., Urologist

“After trying single agents with limited success, the HESHE ED Pack allowed us to find the right balance of effectiveness and minimal side effects.” — Michael T., 54

“As a cardiologist, I appreciate the structured approach that allows for careful titration and monitoring in patients with cardiovascular risk factors.” — Dr. Lisa W., Cardiologist

“The convenience and clinical rationale behind this combination pack make it a valuable option in our practice for appropriate patients.” — Dr. James K., Internal Medicine