Diflucan: Effective Single-Dose Oral Antifungal Treatment
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.46 | $43.86 (0%) | 🛒 Add to cart |
| 60 | $1.10 | $87.72 $66.22 (25%) | 🛒 Add to cart |
| 90 | $0.98 | $131.58 $88.58 (33%) | 🛒 Add to cart |
| 120 | $0.92 | $175.44 $110.94 (37%) | 🛒 Add to cart |
| 180 | $0.86 | $263.16 $154.80 (41%) | 🛒 Add to cart |
| 270 | $0.82
Best per pill | $394.74 $221.02 (44%) | 🛒 Add to cart |
| Product dosage: 150mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.86 | $55.90 (0%) | 🛒 Add to cart |
| 60 | $1.39 | $111.80 $83.42 (25%) | 🛒 Add to cart |
| 90 | $1.23 | $167.70 $110.94 (34%) | 🛒 Add to cart |
| 120 | $1.16 | $223.60 $139.32 (38%) | 🛒 Add to cart |
| 180 | $1.08 | $335.40 $194.36 (42%) | 🛒 Add to cart |
| 270 | $1.03
Best per pill | $503.10 $277.78 (45%) | 🛒 Add to cart |
| Product dosage: 200mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $2.92 | $87.72 (0%) | 🛒 Add to cart |
| 60 | $2.12 | $175.44 $127.28 (27%) | 🛒 Add to cart |
| 90 | $1.84 | $263.16 $165.98 (37%) | 🛒 Add to cart |
| 120 | $1.71 | $350.88 $205.54 (41%) | 🛒 Add to cart |
| 180 | $1.57 | $526.32 $282.94 (46%) | 🛒 Add to cart |
| 270 | $1.49
Best per pill | $789.48 $401.62 (49%) | 🛒 Add to cart |
| Product dosage: 400mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $4.87 | $146.20 (0%) | 🛒 Add to cart |
| 60 | $3.65 | $292.40 $219.30 (25%) | 🛒 Add to cart |
| 90 | $3.26 | $438.60 $293.26 (33%) | 🛒 Add to cart |
| 120 | $3.06 | $584.80 $367.22 (37%) | 🛒 Add to cart |
| 180 | $2.86 | $877.20 $514.28 (41%) | 🛒 Add to cart |
| 270 | $2.72
Best per pill | $1315.80 $734.44 (44%) | 🛒 Add to cart |
Diflucan (fluconazole) is a systemic antifungal medication indicated for the treatment and prevention of a range of fungal and yeast infections. As a triazole antifungal agent, it functions by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, leading to cell death. Its broad-spectrum activity, excellent oral bioavailability, and proven clinical efficacy make it a first-line choice for both uncomplicated and invasive fungal infections in appropriate patient populations.
Features
- Active ingredient: Fluconazole 50 mg, 100 mg, 150 mg, or 200 mg tablets
- Formulation: Oral tablet or suspension; also available in intravenous form
- Mechanism: Selective inhibition of fungal cytochrome P450-dependent enzyme lanosterol 14-α-demethylase
- Spectrum: Active against Candida species, Cryptococcus neoformans, and certain dermatophytes
- Pharmacokinetics: >90% oral bioavailability, extensive tissue penetration including CSF
- Half-life: Approximately 30 hours, allowing for once-daily dosing
Benefits
- Provides rapid and effective resolution of symptomatic vaginal yeast infections, often with a single oral dose
- Reduces risk of recurrence in patients with frequent or severe fungal infections when used prophylactically
- Offers convenient oral administration compared to topical antifungal regimens, improving patient compliance
- Demonstrates reliable efficacy in immunocompromised patients, including those with HIV/AIDS or undergoing chemotherapy
- Shows excellent penetration into cerebrospinal fluid, making it valuable in treating cryptococcal meningitis
- Allows for flexible dosing regimens tailored to infection severity and patient renal function
Common use
Diflucan is commonly prescribed for the treatment of vaginal candidiasis, oropharyngeal and esophageal candidiasis, cryptococcal meningitis, and systemic Candida infections. It is also used prophylactically to prevent fungal infections in patients undergoing bone marrow transplantation who receive cytotoxic chemotherapy and/or radiation therapy. Off-label uses include treatment of fungal urinary tract infections, candidal balanitis, and tinea versicolor when topical therapy is insufficient or impractical.
Dosage and direction
For vaginal candidiasis: A single 150 mg oral dose. For oropharyngeal candidiasis: 200 mg on first day, then 100 mg once daily for at least 14 days. For esophageal candidiasis: 200 mg on first day, then 100 mg once daily; may increase to 400 mg daily if needed. For cryptococcal meningitis: 400 mg on first day, then 200-400 mg once daily for 10-12 weeks after cerebrospinal fluid becomes culture-negative. For maintenance therapy to prevent relapse of cryptococcal meningitis in patients with AIDS: 200 mg once daily. Dosage must be adjusted in patients with renal impairment (CrCl <50 mL/min). Tablets may be taken with or without food.
Precautions
Hepatic function should be monitored during prolonged therapy, as rare cases of serious hepatic toxicity have been reported. Patients who develop abnormal liver function tests during Diflucan therapy should be monitored for the development of more severe hepatic injury. Electrolyte imbalance, particularly hypokalemia, should be corrected prior to initiation of therapy. Use with caution in patients with potential for proarrhythmic conditions. Adrenal function should be monitored in patients receiving prolonged therapy. Pregnancy should be excluded before initiating treatment for vaginal candidiasis.
Contraindications
Hypersensitivity to fluconazole, other azole antifungal agents, or any component of the formulation. Coadministration with cisapride, erythromycin, pimozide, or quinidine due to potential for QT prolongation and serious cardiac arrhythmias. Use in patients with congenital long QT syndrome or those with clinical conditions known to prolong the QT interval.
Possible side effect
Common: Headache (13%), nausea (7%), abdominal pain (6%), diarrhea (3%), dyspepsia (1%), dizziness (1%), taste perversion (1%). Less common: Rash, vomiting, increased liver enzymes, hypercholesterolemia, hypokalemia. Rare but serious: Hepatotoxicity (including fatal hepatic necrosis), anaphylaxis, QT prolongation, torsades de pointes, seizures, exfoliative skin disorders, leukopenia, thrombocytopenia.
Drug interaction
Significant interactions occur with drugs metabolized by CYP3A4 and CYP2C9. Increases concentrations of: warfarin (monitor PT/INR), phenytoin, cyclosporine, rifabutin, theophylline, zidovudine, oral hypoglycemics, statins, benzodiazepines, calcium channel blockers, and sirolimus. Concentrations decreased by: rifampin, isoniazid. Avoid concomitant use with terfenadine, astemizole, cisapride, pimozide, or quinidine. May reduce efficacy of oral contraceptives.
Missed dose
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one. For single-dose regimens (such as for vaginal candidiasis), if the dose is missed and symptoms persist, consult a healthcare provider for guidance.
Overdose
Symptoms may include paranoid behavior, auditory and visual hallucinations, and nausea. Gastric lavage may be indicated if performed soon after ingestion. As fluconazole is largely excreted in urine, forced diuresis would likely increase elimination. Hemodialysis for 3 hours reduces plasma concentrations by approximately 50%. There is no specific antidote; treatment should be symptomatic and supportive.
Storage
Store at controlled room temperature 20-25°C (68-77°F). Protect from moisture. Keep container tightly closed. Do not remove desiccant from bottle. Keep out of reach of children. Do not use after expiration date printed on packaging. For the oral suspension, store reconstituted suspension between 5-30°C (41-86°F) and discard unused portion after 2 weeks.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Diflucan is a prescription medication that should be used only under the supervision of a qualified healthcare provider. Proper diagnosis and treatment selection should be made by a physician based on individual patient factors. Never self-medicate with antifungal agents. Report any adverse effects to your healthcare provider promptly.
Reviews
“After struggling with recurrent vaginal yeast infections for years, a single dose of Diflucan provided complete resolution within 48 hours. The convenience of oral administration compared to messy creams was remarkable.” - Verified Patient
“As an infectious disease specialist, I find Diflucan to be an invaluable tool in my practice. Its predictable pharmacokinetics and excellent tissue penetration make it particularly useful for treating cryptococcal meningitis in our HIV-positive population.” - Medical Professional
“While effective for my yeast infection, I experienced significant nausea and headache after taking the 150 mg dose. The symptoms resolved within 24 hours, but the initial discomfort was notable.” - Verified Patient
“The prophylactic use of Diflucan in our transplant patients has significantly reduced the incidence of invasive fungal infections. The once-daily dosing regimen supports excellent compliance in this vulnerable population.” - Transplant Specialist