Augmentin is a widely prescribed combination antibiotic containing amoxicillin and clavulanate potassium. It belongs to the penicillin class of antibiotics and is specifically formulated to overcome bacterial resistance mechanisms. This medication is indicated for the treatment of a diverse range of bacterial infections affecting various organ systems. Its enhanced spectrum of activity makes it a first-line choice for many common and complicated community-acquired infections. Healthcare providers rely on Augmentin for its proven efficacy and well-established safety profile when used appropriately.

Features

• Combination of amoxicillin (a beta-lactam antibiotic) and clavulanate potassium (a beta-lactamase inhibitor)
• Available in multiple formulations: tablets (including chewable), oral suspension, and intravenous injection
• Various strength options: 250mg, 500mg, and 875mg amoxicillin components with fixed clavulanate ratios
• Extended-spectrum activity against Gram-positive and Gram-negative bacteria
• Acid-stable formulation for reliable oral absorption
• FDA-approved for multiple infection sites and patient populations

Benefits

• Effectively treats infections caused by beta-lactamase producing bacteria that are resistant to amoxicillin alone
• Provides broad coverage against common pathogens in respiratory, skin, and urinary tract infections
• Rapid bactericidal action helps achieve quick clinical improvement
• Well-established dosing protocols for various age groups and renal functions
• Multiple formulation options allow for flexible administration across patient populations
• Demonstrated efficacy in both community and hospital settings for appropriate indications

Common use

Augmentin is commonly prescribed for bacterial infections including acute bacterial sinusitis, community-acquired pneumonia, acute otitis media, skin and skin structure infections, and urinary tract infections. It is particularly effective against Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, Staphylococcus aureus, and Escherichia coli. The medication is also used in dental infections, animal bite wounds, and as prophylactic coverage in certain surgical procedures. Healthcare providers select Augmentin when coverage beyond standard penicillins is required due to suspected or confirmed beta-lactamase producing organisms.

Dosage and direction

Dosage varies based on infection severity, pathogen susceptibility, and patient factors. For mild to moderate infections: 500mg every 12 hours or 250mg every 8 hours. For severe infections: 875mg every 12 hours or 500mg every 8 hours. Pediatric dosing is based on amoxicillin component (25-45 mg/kg/day divided every 12 hours or 20-40 mg/kg/day divided every 8 hours). Take at the start of a meal to enhance absorption and reduce gastrointestinal side effects. Complete the full course of therapy even if symptoms improve earlier. Dosage adjustment is required in patients with renal impairment (creatinine clearance <30 mL/min requires extended dosing intervals).

Precautions

Use with caution in patients with history of gastrointestinal disease, particularly colitis. Monitor for superinfection or fungal overgrowth during prolonged therapy. Hepatic function should be monitored during prolonged treatment. May cause false-positive urine glucose tests with copper reduction methods. Use with caution in patients with mononucleosis due to increased risk of rash. Elderly patients may be more susceptible to side effects and require dose adjustment based on renal function. Pregnancy Category B: use only if clearly needed after risk-benefit assessment.

Contraindications

History of serious hypersensitivity reactions to amoxicillin, clavulanate, or other beta-lactam antibiotics. Patients with history of Augmentin-associated cholestatic jaundice/hepatic dysfunction. Previous history of Augmentin-related hepatic impairment. Concomitant use with disulfiram (for oral suspension formulation containing alcohol). Patients with phenylketonuria (some formulations contain phenylalanine).

Possible side effect

Common side effects include diarrhea/loose stools (9%), nausea (3%), skin rashes and urticaria (3%), vomiting (1%), and vaginitis (1%). Less frequent effects include abdominal discomfort, headache, and dizziness. Serious side effects may include pseudomembranous colitis, hepatic dysfunction (elevated liver enzymes, hepatitis), hematologic effects (anemia, thrombocytopenia), allergic reactions (anaphylaxis, Stevens-Johnson syndrome), and interstitial nephritis. Dental discoloration may occur with prolonged use but is usually removable by professional cleaning.

Drug interaction

Probenecid decreases renal tubular secretion of amoxicillin, increasing blood levels. Allopurinol may increase incidence of skin rash. May reduce efficacy of oral contraceptives; recommend additional contraceptive methods. Concurrent use with anticoagulants may enhance anticoagulant effect and require more frequent monitoring. Bacteriostatic antibiotics may interfere with bactericidal action of Augmentin. Concomitant administration with methotrexate increases methotrexate serum levels.

Missed dose

Take the missed dose as soon as remembered unless it is almost time for the next scheduled dose. Do not double the dose to make up for a missed dose. Maintain regular dosing intervals to ensure consistent therapeutic blood levels. If multiple doses are missed, contact healthcare provider for guidance on resuming therapy. Setting daily reminders or using pill organizers can help maintain adherence to the prescribed regimen.

Overdose

Symptoms may include gastrointestinal disturbances (nausea, vomiting, diarrhea), electrolyte imbalances, and CNS effects. Management is primarily supportive with attention to fluid and electrolyte balance. Hemodialysis may enhance elimination of both components. Monitor renal function and provide symptomatic treatment. In cases of significant overdose, contact poison control center (1-800-222-1222) or seek emergency medical attention immediately.

Storage

Store tablets at room temperature (20-25°C or 68-77°F) in original container. Keep tightly closed and protect from moisture. Reconstituted oral suspension should be refrigerated (2-8°C or 36-46°F) and discarded after 10 days. Do not freeze. Keep all medications out of reach of children and pets. Do not use beyond expiration date printed on packaging. Protect from light and excessive heat.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any medication. The prescribing physician should make final determinations regarding appropriate therapy based on individual patient factors. Actual product labeling and prescribing information should be consulted for complete details. Dosage may need adjustment based on specific clinical circumstances.

Reviews

Clinical studies demonstrate Augmentin’s efficacy with success rates of 85-95% for approved indications. Healthcare providers appreciate its broad spectrum and reliability in treating mixed infections. Patients report rapid symptom improvement, though some note gastrointestinal side effects. The combination therapy approach is particularly valued for overcoming resistance patterns. Long-term clinical experience supports its position as a cornerstone antibiotic therapy in appropriate clinical scenarios.