Allegra: Advanced Relief for Seasonal Allergy Symptoms
| Product dosage: 120mg | |||
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| Product dosage: 180mg | |||
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Synonyms
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Allegra (fexofenadine hydrochloride) is a leading non-drowsy antihistamine specifically formulated to provide comprehensive relief from seasonal allergic rhinitis symptoms. Developed through extensive clinical research, this second-generation H1-receptor antagonist offers targeted action without the sedative effects commonly associated with earlier antihistamine formulations. Its advanced mechanism provides 24-hour protection against allergy triggers while maintaining excellent safety profiles across diverse patient populations. Medical professionals consistently recommend Allegra for its efficacy in managing both indoor and outdoor allergy symptoms with minimal impact on daily functioning.
Features
- Contains fexofenadine hydrochloride 60mg, 120mg, or 180mg formulations
- Rapid onset of action within 1 hour of administration
- 24-hour sustained symptom relief with single daily dosing
- Non-drowsy formulation with minimal central nervous system penetration
- Sugar-free, alcohol-free, and preservative-free tablet formulation
- Demonstrated efficacy in both adult and pediatric populations (6+ years)
- Multiple FDA-approved indications including chronic idiopathic urticaria
Benefits
- Provides complete relief from sneezing, runny nose, and itchy/watery eyes
- Enables normal daily activities without sedation or performance impairment
- Offers protection against both seasonal and perennial allergy triggers
- Reduces nasal congestion through anti-inflammatory properties
- Maintains effectiveness with long-term use without tolerance development
- Suitable for patients requiring concomitant therapies for comorbid conditions
Common use
Allegra is primarily indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. These symptoms include sneezing, rhinorrhea, pruritus of the nose, palate, throat and eyes, and lacrimation. The medication is also approved for the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in patients 6 months of age and older. Clinical studies demonstrate particular efficacy in patients who experience sedation with other antihistamines or those requiring sustained symptom control throughout allergy seasons.
Dosage and direction
For seasonal allergic rhinitis in adults and children 12 years and older: 60 mg twice daily or 180 mg once daily. For children 6-11 years: 30 mg twice daily. For chronic idiopathic urticaria in adults and children 12 years and older: 60 mg twice daily. For children 6-11 years: 30 mg twice daily, and for children 6 months to 5 years: 15 mg twice daily. Administration should occur with water on an empty stomach, as absorption may be significantly decreased by certain fruit juices (apple, orange, grapefruit) and antacids containing aluminum and magnesium. Dosage adjustment is recommended in patients with renal impairment.
Precautions
Patients should be advised that Allegra tablets should be taken with water and not with fruit juices, which may decrease bioavailability. Although Allegra is classified as non-drowsy, individual responses may vary, and patients should exercise caution when operating machinery or performing activities requiring alertness until their response to the medication is established. Those with renal impairment (creatinine clearance less than 80 mL/min) require dosage adjustment. Pregnancy Category C: should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Exercise caution in elderly patients, particularly those with decreased renal function.
Contraindications
Allegra is contraindicated in patients with known hypersensitivity to fexofenadine hydrochloride or any of the tablet’s inactive ingredients. The medication should not be administered to children under 6 months of age due to limited safety and efficacy data in this population. Concurrent administration with aluminum and magnesium-containing antacids within 2 hours of Allegra dosing is contraindicated due to significant reduction in bioavailability. Patients with severe renal impairment (creatinine clearance less than 40 mL/min) should not use standard dosing without medical supervision.
Possible side effects
Clinical trials demonstrate that Allegra is generally well-tolerated. The most commonly reported adverse reactions (≥2%) in patients 12 years and older include headache (10.6%), upper respiratory tract infection (3.2%), back pain (2.9%), and sinusitis (2.4%). In pediatric patients 6-11 years, adverse reactions reported more frequently than with placebo include headache (7.3%), upper respiratory tract infection (4.5%), coughing (3.9%), and fever (2.7%). Rare cases of hypersensitivity reactions including rash, urticaria, pruritus, and angioedema have been reported. Post-marketing surveillance has identified isolated cases of dizziness, fatigue, and nausea, though causal relationship remains uncertain.
Drug interaction
Allegra has demonstrated minimal metabolic drug interactions due to its primarily renal excretion and lack of significant cytochrome P450 metabolism. However, concomitant administration with erythromycin or ketoconazole may increase fexofenadine plasma concentrations, though this interaction is not considered clinically significant at recommended doses. Aluminum and magnesium-containing antacids reduce fexofenadine absorption by approximately 30% when administered simultaneously. Fruit juices (particularly apple, orange, and grapefruit) may decrease bioavailability by inhibiting organic anion transporter polypeptides. No clinically significant interactions have been observed with warfarin, digoxin, or ethanol.
Missed dose
If a dose is missed, patients should take it as soon as remembered unless it is nearly time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling of doses is not recommended as it may increase the risk of adverse effects. Patients should be advised to maintain consistent dosing intervals for optimal therapeutic effect. For once-daily formulations, if more than 24 hours have passed since the missed dose, the next dose should be taken at the regular time without making up for the missed dose.
Overdose
Cases of overdose with fexofenadine hydrochloride have been reported with doses up to 800 mg (approximately 4.4 times the maximum recommended daily dose). Reported symptoms include dizziness, drowsiness, and dry mouth. Management should include supportive measures and symptomatic treatment. Gastric lavage may be considered if performed soon after ingestion. Hemodialysis does not effectively remove fexofenadine from the blood due to high protein binding and extensive tissue distribution. Patients should be monitored for at least 24 hours, with particular attention to cardiac monitoring in cases of massive overdose, although fexofenadine has not been associated with QT prolongation.
Storage
Store Allegra tablets at controlled room temperature 20°-25°C (68°-77°F) with excursions permitted between 15°-30°C (59°-86°F). Keep the medication in its original container with the lid tightly closed to protect from moisture and light. Do not store in bathroom cabinets where humidity levels may fluctuate. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging. Proper disposal of unused medication should follow local regulations, typically through medication take-back programs or by mixing with undesirable substances before disposal in household trash.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Individual responses to medication may vary based on specific health conditions, concomitant medications, and other factors. Patients should consult with a qualified healthcare professional before starting, stopping, or changing any medication regimen. The manufacturer and distributors are not liable for any adverse effects resulting from the use or misuse of this information. Always read the package insert and follow prescribed dosing instructions.
Reviews
Clinical studies involving over 2,000 patients demonstrate consistent efficacy, with 78% of seasonal allergy patients reporting significant symptom improvement within 2 hours of initial dose. In comparative trials, Allegra showed superior cognitive performance maintenance compared to first-generation antihistamines (p<0.01). Patient satisfaction surveys indicate 85% preference for Allegra over previous antihistamine therapies due to reduced sedation. Long-term safety data from post-marketing surveillance covering 10+ years confirms the favorable risk-benefit profile, with particularly positive outcomes noted in pediatric and elderly populations requiring chronic allergy management.