Acivir Pills: Effective Antiviral Treatment for Herpes Infections
| Product dosage: 200mg | |||
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Acivir Pills contain the active ingredient acyclovir, a nucleoside analogue DNA polymerase inhibitor specifically designed to combat herpes virus infections. This oral formulation is a cornerstone in the management of both initial and recurrent episodes of herpes simplex and herpes zoster, offering systemic antiviral action that suppresses viral replication. By interfering with viral DNA synthesis, Acivir reduces the severity and duration of outbreaks, minimizes the risk of complications, and in some cases, can be used for chronic suppression. It is a well-established, clinically proven option prescribed by healthcare professionals worldwide for its targeted mechanism and favorable safety profile.
Features
- Contains 200mg, 400mg, or 800mg acyclovir as the active pharmaceutical ingredient
- Available as film-coated tablets for ease of administration and improved tolerability
- Manufactured under strict GMP (Good Manufacturing Practice) standards ensuring consistency and purity
- Exhibits high bioavailability and selective activation in virus-infected cells
- Stable at room temperature with a long shelf life
Benefits
- Significantly shortens the healing time of lesions in herpes simplex virus (HSV-1 and HSV-2) outbreaks
- Reduces the duration of viral shedding, lowering the risk of transmission to others
- Alleviates associated symptoms such as pain, burning, and itching more rapidly
- Can decrease the frequency of recurrent episodes when used as suppressive therapy
- Helps prevent complications in immunocompromised patients, such as disseminated infections
- Supports improved quality of life by minimizing the physical and emotional impact of recurrent herpes
Common use
Acivir Pills are primarily indicated for the treatment of infections caused by herpes viruses. This includes genital herpes (both initial and recurrent episodes), herpes labialis (cold sores), herpes zoster (shingles), and chickenpox in immunocompetent patients. They are also used for the suppression of recurrent genital herpes and for prophylaxis in immunocompromised individuals (such as HIV patients or transplant recipients) to prevent herpes virus reactivation. Off-label uses may include management of herpes simplex encephalitis or eczema herpeticum, though these typically involve intravenous formulations.
Dosage and direction
Dosage must be individualized based on the indication, renal function, and immunologic status of the patient. For treatment of genital herpes: 200 mg orally five times daily for 10 days (initial episode) or 400 mg three times daily for 5 days (recurrent episode). For chronic suppression: 400 mg twice daily. For herpes zoster: 800 mg five times daily for 7–10 days. For chickenpox: 20 mg/kg (up to 800 mg) four times daily for 5 days. Tablets should be taken with a full glass of water, with or without food. Dosage adjustment is necessary in patients with renal impairment (creatinine clearance <25 mL/min). Treatment should be initiated at the earliest sign or symptom for maximum efficacy.
Precautions
Patients should be advised to maintain adequate hydration to prevent crystalluria and renal impairment. Use with caution in elderly patients due to age-related decline in renal function. Not a cure for herpes infections; does not eliminate the virus or prevent transmission entirely. Caution advised in patients with neurological abnormalities or those receiving concomitant nephrotoxic drugs. Patients should avoid sexual contact during outbreaks to reduce transmission risk even if symptoms are mild. Inform healthcare provider of any history of kidney disease, dehydration, or electrolyte imbalances.
Contraindications
Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation. Contraindicated in patients with severe renal impairment (creatinine clearance <10 mL/min) without appropriate dose adjustment. Should not be used in patients with known hypersensitivity reactions to previous antiviral nucleoside analogues.
Possible side effect
Common side effects include nausea (5–8%), vomiting (2–3%), diarrhea (2–4%), and headache (2–5%). Less frequently, dizziness, fatigue, and skin rash may occur. Rare but serious adverse effects include acute renal failure, neurological symptoms (agitation, confusion, hallucinations, tremors—more common in elderly or renally impaired patients), thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), and hepatitis. Hematologic changes such as leukopenia and thrombocytopenia have been reported in immunocompromised patients.
Drug interaction
Probenecid may decrease renal clearance of acyclovir, increasing plasma concentrations and risk of toxicity. Concurrent use with other nephrotoxic agents (e.g., aminoglycosides, cyclosporine, NSAIDs) may enhance the risk of renal dysfunction. Zidovudine may potentiate fatigue and lethargy. No significant interactions with oral contraceptives or most commonly used medications have been documented, though caution is advised with drugs eliminated renally.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one. Consistent dosing is important for maintaining effective antiviral concentrations, especially during acute treatment phases.
Overdose
Symptoms of overdose may include agitation, coma, seizures, and renal impairment (elevated BUN and creatinine). Management is supportive and includes maintaining adequate hydration to promote renal excretion. Hemodialysis significantly enhances the removal of acyclovir from the plasma and is recommended in cases of significant overdose, especially in patients with underlying renal insufficiency.
Storage
Store at room temperature (15–30°C or 59–86°F) in a dry place, protected from light and moisture. Keep in the original container with the lid tightly closed. Do not store in bathrooms or near sinks. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new medication or changing your treatment plan. Individual response to therapy may vary. Not all uses or precautions are covered here; refer to the full prescribing information for comprehensive details.
Reviews
Clinical studies and meta-analyses consistently demonstrate the efficacy of oral acyclovir (Acivir) in reducing the duration of symptoms and viral shedding in herpes infections. A systematic review in The Cochrane Database confirmed its superiority over placebo in episodes of genital herpes. Long-term use for suppression is well-tolerated, with many patients reporting fewer and less severe recurrences. Some reviews note gastrointestinal discomfort as a drawback, but overall, it remains a first-line treatment in guidelines issued by infectious disease societies. Patient-reported outcomes often highlight improved confidence and daily functioning with suppressive therapy.