Naprosyn (naproxen) is a trusted nonsteroidal anti-inflammatory drug (NSAID) widely prescribed for managing moderate pain, inflammation, and stiffness associated with conditions such as arthritis, tendonitis, and acute musculoskeletal injuries. As a potent inhibitor of prostaglandin synthesis, it offers both analgesic and anti-inflammatory benefits, making it a versatile option in both acute and chronic therapeutic regimens. Its proven efficacy and well-documented safety profile have established it as a frontline treatment in rheumatology and general practice.

Features

• Active ingredient: Naproxen
• Available in 250 mg, 375 mg, and 500 mg tablets
• Also supplied as oral suspension and delayed-release formulations
• Prescription strength; some forms available over-the-counter at lower doses
• Class: Nonsteroidal anti-inflammatory drug (NSAID)
• Half-life: Approximately 12–17 hours, allowing for twice-daily dosing

Benefits

• Provides effective relief from inflammatory pain, reducing discomfort and improving mobility
• Decreases joint swelling and tenderness in arthritic conditions
• Offers prolonged duration of action, supporting consistent symptom control
• Helps reduce fever in addition to pain and inflammation
• Suitable for both acute injuries and chronic inflammatory disorders
• Available in multiple formulations to accommodate individual patient needs

Common use

Naprosyn is commonly used for the management of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile arthritis, gout, bursitis, and tendonitis. It is also prescribed for mild to moderate pain, including dysmenorrhea, headache, dental pain, and postoperative pain. In some cases, it is used off-label for conditions like pericarditis or certain types of chronic back pain.

Dosage and direction

Dosage should be individualized based on the condition being treated and patient response. For arthritis: 250–500 mg twice daily. For acute pain or dysmenorrhea: 500 mg initially, followed by 250 mg every 6–8 hours as needed, not to exceed 1250 mg per day. Tablets should be taken with a full glass of water, with food or milk to minimize gastrointestinal upset. Do not crush, break, or chew delayed-release tablets. Always use the lowest effective dose for the shortest duration possible.

Precautions

Patients should be advised to avoid alcohol and tobacco use while taking Naprosyn, as these may increase the risk of gastrointestinal bleeding. Use with caution in patients with a history of cardiovascular disease, hypertension, fluid retention, heart failure, or kidney impairment. Regular monitoring of renal function, blood pressure, and hemoglobin may be warranted during long-term therapy. Elderly patients may be more susceptible to adverse effects.

Contraindications

Naprosyn is contraindicated in patients with known hypersensitivity to naproxen, aspirin, or other NSAIDs. It should not be used in those who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Avoid use in patients with a history of gastrointestinal bleeding or perforation related to previous NSAID therapy. Do not administer during the third trimester of pregnancy or in patients with severe heart failure.

Possible side effect

Common side effects may include nausea, dyspepsia, heartburn, abdominal pain, dizziness, headache, and drowsiness. Less frequently, edema, tinnitus, pruritus, skin rash, or visual disturbances may occur. Serious side effects can include gastrointestinal bleeding, hepatotoxicity, renal impairment, hypertension, heart failure, and severe skin reactions. Patients should seek immediate medical attention for symptoms such as black stools, vomiting blood, chest pain, shortness of breath, weakness on one side of the body, or slurred speech.

Drug interaction

Naprosyn may interact with anticoagulants (e.g., warfarin), antiplatelet agents, SSRIs, corticosteroids, ACE inhibitors, angiotensin II receptor blockers, diuretics, lithium, methotrexate, cyclosporine, and other NSAIDs, increasing the risk of bleeding, nephrotoxicity, or other adverse effects. Concomitant use with other NSAIDs or aspirin is not recommended. Always inform your healthcare provider of all medications, including over-the-counter drugs and supplements.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule. If uncertain, contact a healthcare provider for guidance.

Overdose

Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, gastrointestinal bleeding, coma, or acute renal failure. In case of suspected overdose, seek emergency medical attention immediately. Treatment is supportive and may include gastric lavage, activated charcoal, and symptomatic care. Hemodialysis is not effective due to high protein binding.

Storage

Store at room temperature (20–25°C or 68–77°F), away from moisture, light, and heat. Keep in the original container, tightly closed. Do not store in the bathroom. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

Naprosyn has been widely studied and is generally well-regarded in clinical practice for its efficacy in reducing pain and inflammation. Many patients report significant improvement in quality of life, particularly those with chronic arthritic conditions. However, individual responses may vary, and some users experience side effects, especially with long-term use. Always follow your healthcare provider’s recommendations and report any adverse reactions promptly.