Motilium (domperidone) is a dopamine antagonist medication specifically designed to address upper gastrointestinal motility disorders. It is widely prescribed by healthcare professionals to manage symptoms such as nausea, vomiting, bloating, and discomfort associated with delayed gastric emptying. By enhancing the natural peristaltic movements of the stomach and duodenum, Motilium facilitates smoother digestion and provides prompt symptomatic relief. Its mechanism of action focuses on blocking dopamine receptors in the gut and chemoreceptor trigger zone, which helps reduce emetic signals and improve gastric emptying without significant central nervous system penetration. Available in tablet and suspension forms, it is a trusted option for both acute and chronic gastrointestinal complaints under medical supervision.

Features

• Active ingredient: Domperidone 10mg per tablet
• Formulations: Oral tablets and suspension
• Rapid onset of action, typically within 30–60 minutes
• Selective peripheral dopamine D₂ and D₃ receptor antagonist
• Minimal blood-brain barrier penetration
• Manufactured under strict pharmaceutical quality standards

Benefits

• Effectively reduces episodes of nausea and vomiting
• Accelerates gastric emptying and improves digestive comfort
• Alleviates symptoms of functional dyspepsia and bloating
• Supports better nutritional intake by minimizing gastrointestinal distress
• Suitable for short-term and supervised long-term use in indicated conditions
• Well-tolerated profile with a lower risk of extrapyramidal side effects compared to central antiemetics

Common use

Motilium is commonly prescribed for the management of nausea and vomiting of various origins, including those associated with gastroenteritis, medication-induced symptoms, migraine, and functional gastrointestinal disorders. It is also used off-label in some regions to stimulate lactation, although this application requires careful risk-benefit evaluation. Patients with diabetic gastroparesis may benefit from its prokinetic effects, though use should be limited to the shortest effective duration. Always use under professional guidance to ensure appropriate indication and dosing.

Dosage and direction

The standard adult dosage is one 10mg tablet taken three to four times daily, preferably 15–30 minutes before meals and at bedtime. Maximum daily intake should not exceed 30mg. For pediatric patients (body weight >35kg), dosage is weight-adjusted and must be determined by a physician. Tablets should be swallowed whole with water; the oral suspension must be shaken well before use. Treatment duration is generally short-term; prolonged use requires periodic reevaluation. Do not exceed prescribed dosage or frequency.

Precautions

Use with caution in patients with hepatic impairment, as metabolism occurs primarily in the liver. Electrolyte imbalances or dehydration should be corrected before initiation. Avoid in patients with known or suspected mechanical gastrointestinal obstruction. Use in elderly patients may require dose adjustment due to potential QT interval prolongation. Pregnancy and breastfeeding require strict medical supervision—domperidone excretes in breast milk. Regular cardiac monitoring is advised in individuals with underlying heart conditions or those on concomitant QT-prolonging drugs.

Contraindications

Motilium is contraindicated in patients with known hypersensitivity to domperidone or any excipients. It must not be used in those with preexisting prolongation of cardiac conduction intervals, especially QTc, or in patients with significant electrolyte disturbances. Contraindications also include severe hepatic impairment, prolactinoma, and co-administration with potent CYP3A4 inhibitors. Avoid in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation.

Possible side effects

Common side effects may include dry mouth, headache, diarrhea, or abdominal cramps. Less frequently, patients may experience nervousness, drowsiness, or changes in libido. Elevated prolactin levels may lead to galactorrhea, gynecomastia, or menstrual irregularities. Although rare, serious side effects such as QT prolongation, cardiac arrhythmias, or anaphylactic reactions have been reported. Discontinue use and seek medical attention if symptoms such as palpitations, syncope, or allergic manifestations occur.

Drug interaction

Domperidone is primarily metabolized by CYP3A4; concomitant use with strong inhibitors of this enzyme (e.g., ketoconazole, erythromycin, clarithromycin, ritonavir) is contraindicated due to increased domperidone exposure and risk of QT prolongation. Use caution with other QT-prolonging agents such as antipsychotics, antiarrhythmics, and certain antidepressants. Anticholinergic drugs may antagonize Motilium’s prokinetic effects. Always inform your healthcare provider of all medications, including over-the-counter products and herbal supplements.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next scheduled dose. Do not double the dose to make up for a missed one. Resume the regular dosing schedule. Consistent timing optimizes therapeutic efficacy, especially when taken before meals.

Overdose

Symptoms of overdose may include agitation, confusion, seizures, and extrapyramidal reactions. Cardiac manifestations such as arrhythmias or QT prolongation may occur. There is no specific antidote; treatment is supportive and symptomatic. Gastric lavage and activated charcoal may be considered if ingestion is recent. Cardiac monitoring is essential in suspected overdose. Contact a poison control center or seek emergency medical attention immediately.

Storage

Store at room temperature (15–30°C) in a dry place, protected from light and moisture. Keep the bottle tightly closed. Do not freeze the suspension. Keep out of reach of children and pets. Discard any unused suspension after 14 days of opening. Do not use beyond the expiration date printed on the packaging.

Disclaimer

This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting or altering any medication regimen. Do not disregard or delay seeking medical advice based on content provided here. Individual patient needs may vary.

Reviews

Clinical studies and patient reports generally reflect satisfaction with Motilium’s efficacy in controlling nausea and vomiting, particularly in postoperative and chemotherapy contexts. Some users note rapid symptom relief and improved quality of life. Criticisms occasionally mention side effects such as dry mouth or headache. Overall, it is regarded as a valuable agent in gastrointestinal symptom management when used appropriately under medical supervision.