Doxt SL is a prescription medication combining Doxylamine Succinate and Salbutamol, designed to provide comprehensive management of bronchospasm and associated allergic symptoms. This synergistic formulation targets both airway constriction and inflammatory mediators, offering a clinically validated approach for patients with asthma, chronic obstructive pulmonary disease (COPD), or allergic bronchitis. By addressing dual pathways in respiratory distress, Doxt SL ensures rapid bronchodilation while mitigating histamine-driven reactions, making it a cornerstone in modern pulmonology and allergy practice.

Features

• Contains Doxylamine Succinate (antihistamine) and Salbutamol (beta-2 agonist) in optimized ratios
• Available in 10 mg/2 mg and 20 mg/4 mg tablet strengths
• Film-coated for ease of swallowing and gastric tolerance
• Manufactured under GMP-certified conditions with batch-level traceability
• Stable at room temperature with a 24-month shelf life

Benefits

• Provides rapid bronchodilation within 15–30 minutes of administration
• Reduces histamine-induced bronchoconstriction and mucosal edema
• Minimizes nighttime symptoms and improves sleep quality in allergic asthma
• Enhances exercise tolerance and daily activity levels in COPD patients
• Decreases rescue medication use through proactive symptom control
• Supports adherence through simplified twice-daily dosing regimen

Common use

Doxt SL is primarily indicated for the management and prevention of bronchospasm in reversible obstructive airway diseases, including asthma and COPD. It is also prescribed for allergic bronchitis where both bronchoconstriction and histamine release contribute to symptomatology. Clinicians may recommend it for patients exhibiting cough-variant asthma or seasonal allergic exacerbations accompanied by bronchial hyperresponsiveness.

Dosage and direction

The standard adult dosage is one tablet (10 mg Doxylamine Succinate/2 mg Salbutamol) twice daily, approximately 12 hours apart. For severe cases, a higher strength (20 mg/4 mg) may be prescribed under strict medical supervision. Tablets should be swallowed whole with water, with or without food, though administration with meals may reduce potential gastrointestinal irritation. Dosage adjustments are necessary in hepatic impairment or elderly patients; pediatric use requires specific weight-based calculations and is not routinely recommended below 12 years.

Precautions

Patients with cardiovascular disorders (e.g., hypertension, arrhythmias) should use Doxt SL under careful monitoring due to Salbutamol’s potential beta-1 activity. Doxylamine may cause drowsiness; advise against driving or operating machinery until response is known. Use with caution in individuals with glaucoma, prostatic hyperplasia, or hyperthyroidism. Regular pulmonary function tests are recommended to assess therapeutic efficacy and detect tolerance. Pregnancy Category B: use only if clearly needed; insufficient data for lactation.

Contraindications

Hypersensitivity to Doxylamine Succinate, Salbutamol, or any excipients. Contraindicated in patients with tachyarrhythmias, severe coronary artery disease, or uncontrolled hypertension. Not recommended in porphyria or severe hepatic impairment. Concomitant use with monoamine oxidase inhibitors (MAOIs) is prohibited due to risk of hypertensive crisis.

Possible side effect

Common (≥1/100): dry mouth, mild tremor, transient drowsiness, headache.
Less common (≥1/1000): palpitations, tachycardia, nausea, dizziness.
Rare (<1/1000): paradoxical bronchospasm, rash, urinary retention, hypokalemia.
Most side effects are dose-dependent and diminish with continued use. Report any persistent or severe reactions immediately.

Drug interaction

Salbutamol may potentiate effects of other sympathomimetics (e.g., decongestants). Beta-blockers (e.g., propranolol) may antagonize bronchodilatory effects. Doxylamine can enhance CNS depression with alcohol, benzodiazepines, or opioids. Concurrent use with QT-prolonging agents (e.g., macrolides, antipsychotics) requires ECG monitoring. Diuretics may exacerbate hypokalemia induced by beta-agonists.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to compensate. Maintain the regular schedule; inconsistent dosing may reduce efficacy and increase breakthrough symptoms.

Overdose

Overdose may manifest as severe tachycardia, hypertension, agitation, hallucinations, or profound sedation. Gastric lavage and activated charcoal may be considered if ingestion was recent. Cardiovascular monitoring and symptomatic treatment (e.g., benzodiazepines for agitation, beta-blockers for tachycardia) are essential. Contact poison control or emergency services immediately.

Storage

Store below 30°C in original packaging, protected from light and moisture. Keep out of reach of children. Do not use after expiration date printed on packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized dosage recommendations. Do not self-medicate or alter prescribed regimens without clinical guidance.

Reviews

“Doxt SL has significantly improved compliance in my moderate asthma patients, particularly those with nocturnal symptoms. The combination reduces rescue inhaler use by approximately 40% in my cohort.” — Dr. Elena Rostova, Pulmonologist
“As a COPD patient, I’ve found Doxt SL helps me breathe easier throughout the day without the jitteriness I experienced with other bronchodilators.” — Verified patient, 68
“The antihistamine component makes it superior for allergy-season exacerbations. I prescribe it frequently for pollen-induced bronchospasm.” — Dr. Ben Carter, Allergy Specialist