Avapro (irbesartan) is an angiotensin II receptor blocker (ARB) prescribed for the management of hypertension. It works by blocking the action of certain natural substances that tighten blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently. This medication is also indicated for the treatment of diabetic nephropathy in patients with type 2 diabetes and hypertension, offering renal protection by reducing proteinuria. Clinical studies support its efficacy in lowering both systolic and diastolic blood pressure with a favorable side effect profile. Avapro is available in tablet form and is typically administered once daily for consistent 24-hour control.

Features

• Active ingredient: Irbesartan
• Available in 75 mg, 150 mg, and 300 mg film-coated tablets
• Once-daily dosing for sustained effect
• Belongs to the angiotensin II receptor blocker (ARB) class
• FDA-approved for hypertension and diabetic nephropathy
• Not a controlled substance

Benefits

• Effectively lowers high blood pressure, reducing strain on the heart and arteries
• Decreases the risk of stroke, heart attack, and kidney problems associated with hypertension
• Provides renal protection in type 2 diabetic patients by slowing the progression of kidney disease
• Offers 24-hour blood pressure control with a single daily dose, supporting adherence
• Generally well-tolerated with a low incidence of side effects like cough compared to ACE inhibitors
• Does not usually cause potassium loss or require routine potassium supplementation

Common use

Avapro is primarily used for the treatment of hypertension (high blood pressure) in adults. It may be used alone or in combination with other antihypertensive agents. Additionally, it is indicated for the treatment of diabetic nephropathy (kidney disease) in patients with type 2 diabetes mellitus and hypertension, as it has been shown to reduce the rate of progression of nephropathy as evidenced by the occurrence of doubling of serum creatinine, end-stage renal disease, or death.

Dosage and direction

The recommended initial dose of Avapro for hypertension is 150 mg taken orally once daily. The dosage may be increased to 300 mg once daily if blood pressure is not adequately controlled. For volume-depleted patients, consider initiating therapy at 75 mg. In the treatment of diabetic nephropathy, the recommended maintenance dose is 300 mg once daily. Avapro may be taken with or without food. It is important to take this medication at the same time each day to maintain consistent blood levels. Do not crush or chew the tablet; swallow it whole with a glass of water.

Precautions

Before taking Avapro, inform your healthcare provider if you have a history of kidney disease, liver disease, heart conditions, or if you are on a salt-restricted diet. This drug may cause dizziness or lightheadedness; avoid driving or operating machinery until you know how it affects you. Use caution when rising from a sitting or lying position to prevent falls due to dizziness. Regular monitoring of blood pressure, kidney function, and electrolyte levels is advised during treatment. Avapro should not be used during pregnancy due to the risk of harm to the fetus.

Contraindications

Avapro is contraindicated in patients with a known hypersensitivity to irbesartan or any component of the formulation. Do not use in patients with a history of angioedema related to previous treatment with an ARB. Concomitant use with aliskiren in patients with diabetes is contraindicated. This medication is also contraindicated during the second and third trimesters of pregnancy due to the risk of fetal injury and death.

Possible side effect

Common side effects may include dizziness, lightheadedness, or upset stomach. These often diminish as your body adjusts to the medication. Less common but more serious side effects can include symptoms of high potassium levels (such as muscle weakness, slow/irregular heartbeat), signs of kidney problems (change in the amount of urine), or severe dizziness/fainting. Although rare, allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing) require immediate medical attention.

Drug interaction

Avapro may interact with other medications, including potassium supplements, potassium-sparing diuretics (e.g., spironolactone), NSAIDs (e.g., ibuprofen), which may reduce the antihypertensive effect and increase the risk of kidney impairment, lithium (may increase lithium levels), and other blood pressure medications, potentially increasing the risk of hypotension. Always inform your doctor of all medications, including over-the-counter drugs and herbal supplements, that you are taking.

Missed dose

If you miss a dose of Avapro, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Consistent daily use is important for maintaining blood pressure control, so try to adhere to your prescribed regimen.

Overdose

Symptoms of Avapro overdose may include severe dizziness, fainting, or unusually fast or slow heartbeat. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Treatment is generally supportive and symptomatic; hypotension may be treated with intravenous normal saline. Dialysis is not effective for removing irbesartan from the body due to high protein binding.

Storage

Store Avapro at room temperature (68°F to 77°F or 20°C to 25°C), away from light, moisture, and heat. Keep the medication in its original container, tightly closed, and out of reach of children and pets. Do not store in the bathroom. Properly discard any expired or unused medication as advised by your pharmacist or local disposal guidelines.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

Clinical trials and post-marketing surveillance indicate that Avapro is effective and generally well-tolerated. Many patients report significant improvements in blood pressure control with minimal side effects. In studies for diabetic nephropathy, it has demonstrated a clear benefit in slowing renal disease progression. Some users note dizziness upon initiation, which often resolves. Adherence is high due to once-daily dosing. Always consult your healthcare provider for personalized assessment and treatment.