Alesse is a combination oral contraceptive pill designed to provide highly effective pregnancy prevention with a low-dose hormonal formulation. It contains a blend of ethinyl estradiol and levonorgestrel, which work synergistically to inhibit ovulation, thicken cervical mucus, and alter the endometrial lining. Trusted by healthcare providers and patients alike, Alesse offers a balance of efficacy, tolerability, and convenience for those seeking reliable birth control. Its well-established safety profile and additional non-contraceptive benefits make it a preferred choice for many individuals.

Features

• Contains 0.10 mg levonorgestrel and 0.02 mg ethinyl estradiol per active tablet
• 21-day active pill regimen followed by a 7-day placebo interval
• Monophasic formulation ensuring consistent hormone levels throughout the cycle
• Small, easy-to-swallow tablets with clear packaging for dose tracking
• Manufactured under strict pharmaceutical quality control standards

Benefits

• Provides over 99% effective pregnancy prevention when taken correctly
• Reduces menstrual cramps and leads to lighter, more regular periods
• May improve acne in some users due to anti-androgenic effects
• Lowers risk of ovarian cysts and ectopic pregnancies
• Decreases incidence of iron-deficiency anemia through reduced menstrual flow
• Offers non-contraceptive health benefits including reduced ovarian and endometrial cancer risk

Common use

Alesse is primarily prescribed for contraception in women of reproductive age. It may also be used off-label for management of moderate acne in women at least 14 years old who have no contraindications to hormonal contraception and desire oral contraception. Some healthcare providers may recommend Alesse for menstrual cycle regulation in women with irregular periods or for management of premenstrual dysphoric disorder (PMDD) symptoms.

Dosage and direction

Take one tablet daily at approximately the same time each day, preferably with food or at bedtime to minimize potential nausea. Begin with the first active tablet on the first day of menstrual bleeding or the first Sunday after menstruation begins. For Sunday starters, use additional contraception for the first 7 days. Follow the 21-day active/7-day placebo sequence, with withdrawal bleeding typically occurring during the placebo week. Always follow your healthcare provider’s specific instructions regarding initiation and continuation.

Precautions

• Not protective against sexually transmitted infections; barrier methods recommended for STI prevention
• Regular blood pressure monitoring recommended as oral contraceptives may increase hypertension risk
• Smoking while using combination oral contraceptives significantly increases cardiovascular risks, especially in women over 35
• May affect glucose tolerance; diabetic patients should monitor blood sugar levels closely
• Reduced efficacy possible with gastrointestinal disorders affecting absorption
• Temporary fertility delay possible after discontinuation; allow several cycles for return to baseline fertility

Contraindications

• History of or current thrombophlebitis or thromboembolic disorders
• Cerebrovascular or coronary artery disease
• Known or suspected carcinoma of the breast or estrogen-dependent neoplasia
• Undiagnosed abnormal genital bleeding
• History of jaundice with prior hormonal contraceptive use
• Hepatic impairment or active liver disease
• Known or suspected pregnancy
• Heavy smoking (≥15 cigarettes daily) in women over 35 years
• Hypertension with vascular involvement
• Diabetes with vascular complications
• Headaches with focal neurological symptoms

Possible side effects

Common (≥1%):

• Nausea, vomiting, or abdominal cramps
• Breast tenderness or enlargement
• Breakthrough bleeding or spotting
• Changes in menstrual flow
• Headache
• Weight changes
• Mood changes

Less common:

• Chloasma (melasma)
• Changes in libido
• Vaginal candidiasis
• Contact lens intolerance
• Fluid retention
• Fatigue

Serious (require immediate medical attention):

• Sudden severe headache
• Visual disturbances
• Severe chest pain or shortness of breath
• Severe leg pain
• Jaundice
• Severe abdominal pain
• Unusual neurological symptoms

Drug interaction

Alesse’s effectiveness may be reduced by:

• Antibiotics (particularly rifampin)
• Anticonvulsants (carbamazepine, phenytoin, topiramate)
• Antiretroviral medications
• St. John’s Wort
• Griseofulvin

May alter effectiveness of:

• Warfarin and other anticoagulants
• Antidiabetic medications
• Beta-blockers
• Theophylline
• Cyclosporine
• Thyroid hormones

Missed dose

If one active tablet is missed (24-48 hours late): Take as soon as remembered, then continue regular schedule. No additional protection needed.

If two active tablets are missed in weeks 1 or 2: Take two tablets as soon as remembered, then two tablets the next day. Resume regular schedule. Use backup contraception for 7 days.

If two active tablets are missed in week 3 or three or more consecutive tablets are missed: Discard current pack, start new pack same day. Use backup contraception for 7 days. Consider emergency contraception if unprotected intercourse occurred.

If placebo tablets are missed: Discard missed tablets and continue regular schedule.

Overdose

Serious ill effects from overdose are not expected. Possible symptoms include nausea, vomiting, and withdrawal bleeding. There is no specific antidote. Treatment should be symptomatic and supportive. In cases of massive overdose, monitor for potential fluid retention. Contact poison control center or healthcare provider for guidance.

Storage

Store at room temperature (15-30°C or 59-86°F) in original container. Protect from light and moisture. Keep out of reach of children and pets. Do not use if tablets appear discolored or show signs of deterioration. Properly dispose of expired medication according to local regulations.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Individual response to medication may vary. Always consult with a qualified healthcare professional before starting, changing, or stopping any medication. The prescribing physician should be aware of the patient’s complete medical history and current medications. Regular follow-up and appropriate screening are recommended for all oral contraceptive users.

Reviews

Clinical studies demonstrate high patient satisfaction with Alesse, particularly regarding cycle control and minimal side effects. Many users report improved acne and reduced menstrual symptoms. Healthcare providers appreciate its reliable efficacy and well-tolerated profile. Long-term users often note consistent performance with minimal breakthrough bleeding after the initial adjustment period. Some individuals may experience side effects during the first 1-3 cycles that typically resolve with continued use.